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Table 5 Mortality rate by stage according to time from diagnosis to antibiotic therapy

From: Prospective international validation of the predisposition, infection, response and organ dysfunction (PIRO) clinical staging system among intensive care and general ward patients

 

ATB within the first hour

ATB within the first 3 h

ATB within the first 6 h

Yes

No

Yes

No

Yes

No

Stage I

n = 427

4.1%

(10/241)

2.2%

(4/186)

3.6%

(11/307)

2.5%

(3/120)

3.4%

(12/357)

2.9%

(2/70)

p value

0.286#

0.572#

1.000#

Stage II

n = 508

16.1%

(45/279)

14.4%

(33/229)

15.6%

(56/359)

14.8%

(22/149)

15.6%

(66/422)

14.0%

(12/86)

p value

0.593*

0.812*

0.693*

Stage III

n = 600

23.8%

(74/311)

24.2%

(70/289)

22.5%

(96/426)

27.6%

(48/174)

23.1%

(116/503)

28.9%

(28/97)

p value

0.903*

0.189*

0.220*

Stage IV

n = 96

25%

(10/40)

41.1%

(23/56)

23.1%

(6/26)

38.6%

(27/70)

16.7%

(3/18)

38.5%

(30/78)

p value

0.102*

0.155*

0.102#

  1. (number of deceased/total number of patients within the group)
  2. ATB antibiotic therapy
  3. *Chi-square test
  4. #Fisher’s exact test