Awake prone position reduces work of breathing in patients with COVID-19 ARDS supported by CPAP

Annals of Intensive Care

Table 2 Respiratory mechanics and gas exchange of the study population during supine position and prone position

	Supine N = 40	Prone N = 40	p	Mean difference^† [95% CI]
Respiratory rate, bpm	20 [17 to 24]	17 [15 to 19]	< 0.001	− 3 [− 4 to − 2]
Tidal volume, ml	431 [359 to 498]	424 [379 to 481]	0.478	− 11 [− 43 to − 21]
Tidal volume, ml/kg	6.9 [6.0 to 7.9]	6.9 [5.7 to to 7.9]	0.517	− 0.16 [− 0.65 to 0.33]
Minute ventilation, l/min	8.6 [7.3 to 10.6]	7.7 [6.6 to 8.6]	< 0.001	− 1.4 [− 1.9 to − 0.8]
PaO₂/ FiO₂ ratio, mmHg	166 [136 to 224]	314 [232 to 398]	< 0.001	138 [108 to 169]
PaO₂, mmHg	114 [90 to 141]	206 [143 to 270]	< 0.001	95 [74 to 116]
PaCO₂, mmHg	38 [3 to 42]	39 [37 to 41]	0.029	1.3 [0.1 to 2.5]
Ventilatory ratio	1.4 [1.3 to 1.6]	1.3 [1.1 to 1.5]	< 0.001	− 0.16 [− 0.25 to − 0.07]
Estimated dead-space fraction, %	41 [3 to 49]	32 [23 to 39]	< 0.001	− 9 [− 14 to − 5]

CI confidence interval, bpm breaths per minute
Data are presented as median [interquartile range] for continuous values unless otherwise specified
^†Supine Position taken as reference