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Table 4 Determinants of one-year mortality in ICU-survivors

From: Patterns of ICU admissions and outcomes in patients with solid malignancies over the revolution of cancer treatment

Characteristics

Alive

Deceased

p

Multivariate analysis

(n = 424)

(n = 510)

Cause-specific hazard [95% CI]

p

Age (years)

67 [59–74]

68 [60–76]

0.18

1.008 [1.007–1.012]

0.03

Male gender

248 (58.5)

297 (58.2)

0.4

  

ICU admission

     

 2007–2012

174 (42.1)

210 (42.2)

0.54

 2013–2018

250 (58.1)

300 (58.8)

 

Type of cancer

  

 < 0.001

  

 Lung

65 (15.3)

139 (27.3)

 Gastrointestinal

116 (27.4)

141 (27.7)

 Urologic

103 (24.3)

109 (21.4)

 Cutaneous

7 (1.7)

14 (2.8)

 Breast

48 (11.3)

26 (5.1)

 Lung cancer

65 (15.3)

139 (27.3)

 < 0.001

1.44 [1.16–1.78]

 < 0.001

 Non-lung cancer

359 (84.7)

371 (72.7)

Stage

  

 < 0.001

  

 Localized

181 (42.7)

73 (14.3)

 Advanced

99 (23.3)

104 (20.4)

 Metastatic

141 (33.3)

329 (64.5)

1.90 [1.53–2.37]

 < 0.001

Status

  

 < 0.001

  

 Newly diagnosed

112 (26.4)

164 (32.2)

 Partial remission

118 (27.8)

80 (15.7)

 Complete remission

116 (27.4)

34 (6.7)

 In progression

78 (18.4)

232 (45.5)

1.39 [1.13–1.72]

0.002

Treatment in the past 3 months

     

 Chemotherapy

172 (40.5)

272 (53.3)

 < 0.001

 Surgery

93 (21.9)

55 (10.8)

1.000

0.78 [0.57–1.05]

0.11

 Immunotherapy/targeted therapy

32 (7.5)

72 (14.1)

0.002

SOFA score

5 [3.75–7]

5 [4–7]

0.379

1.03 [0.99–1.06] a

0.05

Organ failure supports

     

 Invasive mechanical ventilation

121 (28.5)

140 (27.5)

0.519

 Non-invasive mechanical ventilation

54 (12.7)

59 (11.6)

0.657

 Inotropes/vasopressors

91 (21.5)

111 (21.8)

0.975

Renal replacement therapy

49 (11.6)

64 (12.5)

0.717

Admission patterns

     

 Non-specific complications

292 (68.9)

288 (56.5)

 < 0.001

 Specific complications

67 (15.8)

178 (34.9)

 < 0.001

1.75 [1.43–2.15]

 < 0.001

 Adverse event complications

65 (15.3)

44 (8.6)

0.002

 Drug-related adverse event

17 (4.0)

24 (4.7)

0.721

 Procedural adverse event

48 (11.3)

20 (3.9)

 < 0.001

Decision to forgo life-sustaining therapy

11 (2.6)

120 (23.5)

 < 0.001

3.21 [2.54–4.06]

 < 0.001

  1. aThe CSH is related to 1-point increase in the SOFA score