Association of ventilator type with hospital mortality in critically ill patients with SARS-CoV2 infection: a prospective study

Ferré, Alexis; Marquion, Fabien; Delord, Marc; Gros, Antoine; Lacave, Guillaume; Laurent, Virginie; Merceron, Sybille; Paul, Marine; Simon, Christelle; Troché, Gilles; Charbonnel, Clément; Marque-Juillet, Stéphanie; Bruneel, Fabrice; Legriel, Stéphane

doi:10.1186/s13613-022-00981-2

Annals of Intensive Care

Table 2 ICU management and outcomes according to ventilator type in patients with COVID-19-related acute respiratory distress syndrome

From: Association of ventilator type with hospital mortality in critically ill patients with SARS-CoV2 infection: a prospective study

Variables	All patients n = 189	ICU ventilator n = 143 (75.7)	Transport ventilator n = 46 (24.3)	P value	N missing^a
ICU management
High-flow nasal oxygen	112 (59.3)	80 (55.9)	32 (69.6)	0.12
Non-invasive ventilation	48 (25.4)	33 (23.1)	15 (32.6)	0.24
Last PaO₂/FiO₂ ratio before intubation	89 [71–123]	89 [72–123]	84 [69–113]	0.52	28
Ventilatory settings, first day of ARDS
First PaO₂/FiO₂ ratio under invasive MV	139 [99–178]	139 [99–178]	126 [98–174]	0.36	2
Corresponding first FiO₂ under invasive MV	1.0 [0.8–1.0]	1.0 [0.8–1.0]	0.9 [0.7–1.0]	0.02	2
Tidal volume (mL/kg PBW)	6.0 [5.9–6.2]	6.0 [5.9–6.2]	6.0 [6.0–6.1]	0.64	3
Set PEEP, cm H₂O	12 [10–12]	12 [10–12]	12 [10–12]	0.69	2
Plateau pressure (P_PLAT, cm H₂O)	23 [21–25]	23 [21–25]	22 [20–24]	0.23	25
Driving pressure, cm H₂O	10 [9–12]	11 [9–13]	10 [9–11]	0.10	25
Time from ICU admission to intubation (days)	0 [0–1]	0 [0–1]	0 [0–1]	0.34	1
Prone positioning	133 (70.4)	99 (69.2)	34 (73.9)	0.58
Number of prone position sessions	4 [2–7]	4 [2–8]	4 [2–6]	0.43
Inhaled nitric oxide	52 (27.5)	42 (29.4)	10 (21.7)	0.35
ECMO	10 (5.3)	10 (7.0)	0 (0.0)	0.12
Ventilator-associated pneumonia	110 (58.2)	80 (55.9)	30 (65.2)	0.31
Weaning failure (≥ 2 orotracheal intubations)	27 (14.3)	17 (11.9)	10 (21.7)	0.14
Tracheostomy	27 (14.3)	20 (14.0)	7 (15.2)	0.81
Need for vasoactive drugs in the ICU	176 (93.1)	134 (93.7)	42 (91.3)	0.52
Need for renal replacement therapy in the ICU	28 (14.8)	25 (17.5)	3 (6.5)	0.09
Dexamethasone initiated at ICU admission	107 (56.6)	77 (53.9)	30 (65.2)	0.23
Rescue dexamethasone for persistent ARDS	38 (20.1)	30 (21.0)	8 (17.4)	0.68
Outcomes
Duration of invasive MV, days	19 [11–33]	18 [11–32]	21 [13–37]	0.39
ICU length of stay (days)	24 [15–41]	24 [14–40]	27 [15–44]	0.44
ICU mortality	60 (31.8)	47 (32.9)	13 (28.3)	0.59
Post-ICU hospital length of stay (days)	10 [7–15]	11 [8–16]	9 [7–12]	0.10
Hospital mortality	61 (32.3)	48 (33.6)	13 (28.3)	0.59
Rehabilitation-unit length of stay (days)	27 [17–41]	27 [17–41]	31 [21–42]	0.68
Day-90 mortality	63 (33.3)	50 (35.0)	13 (28.3)	0.47

Data are presented as N (%) or Median [interquartile range]
ICU intensive care unit, PaO₂/FiO₂ partial pressure of oxygen to fraction of inspired oxygen, ARDS acute respiratory distress syndrome, PBW predicted body weight, MV mechanical ventilation, PEEP positive end-expiratory pressure, ECMO extracorporeal membrane oxygenation, ARDS acute respiratory distress syndrome
^aNumber of missing observations, unless Ø

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