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Table 1 Clinical and biological characteristics of COVID-19 patients

From: Recombinant human interleukin-7 reverses T cell exhaustion ex vivo in critically ill COVID-19 patients

  All patients (n = 20)
Demographics
 Gender, male (%) 14 (70.0)
 Age 71 [66, 72]
 Body mass index 32 [28–36]
Comorbidities
 Comorbidity (%) 9 (50.0)
 Immunosuppressive therapy (%) 1 (5.6)
 Diabetes (%) 4 (23.5)
Delay from symptom onset, days 9.0 [7.0, 11.0]
Severity scores at admission
 SOFA 5.0 [4.0, 7.0]
 SAPS II 37.0 [30.3, 44.3]
 PaO2/FiO2 116.0 [68.3, 151.5]
Organ failures during ICU stay
 Invasive mechanical ventilation (%) 18 (90)
 Vasoactive drugs (%) 15 (83.3)
 Renal replacement therapy (%) 4 (22.2)
Follow-up  
 Concurrent bacterial infection at D0 (%) 9 (45)
 ICU-acquired infection before D20 (%) 15 (75)
 SOFA score at D20 6.5 [5.00, 8.00]
 Corticotherapy in ICU (%) 18 (90)
 Mechanical ventilation duration 21.5 [16.5, 32.5]
 Days in ICU 28.0 [24.3, 39.5]
 Days in Hospital 32.5 [25.8, 45.8]
 Day-28 mortality 7 (35)
 Day-90 mortality 9 (45)
Status at time of sampling D0 D20
 Invasive mechanical ventilation 8 (40) 14 (70)
 Hospitalized in ICU 20 (100) 20 (100)
Laboratory values D0 (n = 19) D20 (n = 18) p-value
 Lymphocyte (cells/µL) 534 [392, 751] 1 055 [713, 1 488] 0.003
 CD3 + lymphocytes (cells/µL) 355 [214, 445] 760 [422, 967] 0.001
 CD4 + lymphocytes (cells/µL) 189 [117, 316] 415 [228, 590] 0.003
 CD8 + lymphocytes (cells/µL) 103 [82, 198] 262 [114, 430] 0.018
 mHLA-DR expression (Ab/C) 6 548 [4 622, 11 704] 6 855 [5 946, 13 897] 0.741
  1. The results are shown as medians and interquartile ranges [Q1–Q3] for continuous variables or numbers and percentages for categorical variables. SOFA: Sepsis-related organ failure assessment. SAPS II: Simplified acute physiology score II. ICU: Intensive care unit. Continuous laboratory variables were compared with paired Mann–Whitney U test and p-value reported is two-sided. Values were missing for 2 patients at D0 and one patient at D20. Normal values obtained from routine Immunology Lab for total lymphocyte count: [1000–2800] cells/µL, for T lymphocytes: [595 –1861] cells/µL, for CD4 + T cells: [336–1 126] cells/µL, for CD8 + T cells: [125–780] cells/µL, for mHLA-DR: [13,500–45,000] Ab/C (number of antibodies-bound per cell)