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Table 1 Demographic, respiratory and hemodynamics data

From: Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients

Demographic data
Number of patients, n 15
Age, years 53 (50–62)
Male, n (%) 14 (93)
BMI, kg/m2 27 (24–29)
APACHE II, Score 13 (11–16)
Recruitment-to-Inflation Ratio > 0.5, n (%) 8 (53)
Number of days from the symptom’s onset to intubation 14 (11–16)
Ventilation days before enrollment 0.8 (0.3–2.1)
Death in the ICU, n (%) 6 (40)
  Sequential steps
Supine-1 Supine-2 Supine-3 N p
Respiratory parameters
 Driving airway pressure, cmH2O 12.5 ± 2.4 11.6 ± 2.2 11.2 ± 2.1 15  < 0.01
 Respiratory system compliance, mL/cmH2O 28.5 ± 8.5 30.6 ± 8.1 31.6 ± 8.4 15  < 0.01
 Plateau airway pressure, cmH2O 26.8 ± 2.9 25.9 ± 2.7 25.6 ± 2.5 15  < 0.01
 Peak airway pressure, cmH2O 32.4 ± 3.1 31.8 ± 3.3 31.3 ± 2.8 15  < 0.01
 Mean airway pressure, cmH2O 19.3 ± 1.8 19.1 ± 1.8 19.0 ± 1.7 15  < 0.05
 Tidal volume, mL/kg 5.4 ± 0.6 5.4 ± 0.6 5.4 ± 0.6 15 0.11
 Expiratory minute volume, L/min 8.5 ± 1.1 8.6 ± 1.1 8.6 ± 1.1 15 0.12
 Total PEEP, cmH2O 15.5 (12.5–15.8) 15.4 (12.4–16.1) 15.7 (12.7–15.9) 15 0.55
 Resistance, cmH2O/L/min 10.8 ± 1.9 11.3 ± 2.1 11.0 ± 2.0 15 0.38
 Driving transpulmonary pressure, cmH2O 10.9 ± 2.5 10.2 ± 2.3 9.7 ± 2.1 14  < 0.01
 Lung compliance, mL/cmH2O 33.8 ± 10.9 35.7 ± 10.5 37.5 ± 10.5 14 0.01
 Inspiratory transpulmonary pressure, cmH2O 15.9 ± 4.7 15.1 ± 4.5 14.7 ± 3.7 14 0.08
 Expiratory transpulmonary pressure, cmH2O 5.0 ± 3.6 4.9 ± 4.1 5.1 ± 3.1 14 0.8
 Chest wall compliance, mL/cmH2O 245 (188–262) 239 (183–270) 240 (198–291) 14 0.93
Gas exchange
 PaO2/FIO2, mmHg 137.5 ± 36.3 158.4 ± 35.9 163.8 ± 46.1 15  < 0.01
 PaCO2, mmHg 63 (58–75) 64 (52–71) 63 (55–81) 15 0.08
 pH 7.28 ± 0.1 7.28 ± 0.11 7.27 ± 0.1 15 0.61
 SpO2 (%) 96 (95–98) 98 (96–99) 98 (96–99) 15 0.05
 PaCO2–ETCO2 15.8 ± 12.1 15.4 ± 13.4 15.8 ± 12.9 15 0.9
Hemodynamics
 Heart rate, beats/minute 92 ± 18 90 ± 17 90 ± 18 15 0.64
 Systolic arterial pressure, mmHg 127 ± 16 124 ± 19 123 ± 19 15 0.76
 Diastolic arterial pressure, mmHg 68 ± 8 68 ± 11 69 ± 8 15 0.91
 Mean arterial pressure, mmHg 88 ± 10 87 ± 13 88 ± 11 15 0.89
  1. BMI: body mass index; PBW: predicted body weight. PEEP: positive end-expiratory pressure; PaO2/FIO2: partial pressure of oxygen in arterial blood/inspired oxygen fraction ratio; PaCO2: partial pressure of carbon dioxide in arterial blood; SpO2: oxygen saturation; ETCO2: end-tidal CO2; n: number of patients
  2. Continuous variables are shown as mean ± SD or median (IQR) based on their distribution. Mixed model was used to compare the periods in supine position