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Table 1 Demographic, respiratory and hemodynamics data

From: Sequential lateral positioning as a new lung recruitment maneuver: an exploratory study in early mechanically ventilated Covid-19 ARDS patients

Demographic data

Number of patients, n

15

Age, years

53 (50–62)

Male, n (%)

14 (93)

BMI, kg/m2

27 (24–29)

APACHE II, Score

13 (11–16)

Recruitment-to-Inflation Ratio > 0.5, n (%)

8 (53)

Number of days from the symptom’s onset to intubation

14 (11–16)

Ventilation days before enrollment

0.8 (0.3–2.1)

Death in the ICU, n (%)

6 (40)

 

Sequential steps

Supine-1

Supine-2

Supine-3

N

p

Respiratory parameters

 Driving airway pressure, cmH2O

12.5 ± 2.4

11.6 ± 2.2

11.2 ± 2.1

15

 < 0.01

 Respiratory system compliance, mL/cmH2O

28.5 ± 8.5

30.6 ± 8.1

31.6 ± 8.4

15

 < 0.01

 Plateau airway pressure, cmH2O

26.8 ± 2.9

25.9 ± 2.7

25.6 ± 2.5

15

 < 0.01

 Peak airway pressure, cmH2O

32.4 ± 3.1

31.8 ± 3.3

31.3 ± 2.8

15

 < 0.01

 Mean airway pressure, cmH2O

19.3 ± 1.8

19.1 ± 1.8

19.0 ± 1.7

15

 < 0.05

 Tidal volume, mL/kg

5.4 ± 0.6

5.4 ± 0.6

5.4 ± 0.6

15

0.11

 Expiratory minute volume, L/min

8.5 ± 1.1

8.6 ± 1.1

8.6 ± 1.1

15

0.12

 Total PEEP, cmH2O

15.5 (12.5–15.8)

15.4 (12.4–16.1)

15.7 (12.7–15.9)

15

0.55

 Resistance, cmH2O/L/min

10.8 ± 1.9

11.3 ± 2.1

11.0 ± 2.0

15

0.38

 Driving transpulmonary pressure, cmH2O

10.9 ± 2.5

10.2 ± 2.3

9.7 ± 2.1

14

 < 0.01

 Lung compliance, mL/cmH2O

33.8 ± 10.9

35.7 ± 10.5

37.5 ± 10.5

14

0.01

 Inspiratory transpulmonary pressure, cmH2O

15.9 ± 4.7

15.1 ± 4.5

14.7 ± 3.7

14

0.08

 Expiratory transpulmonary pressure, cmH2O

5.0 ± 3.6

4.9 ± 4.1

5.1 ± 3.1

14

0.8

 Chest wall compliance, mL/cmH2O

245 (188–262)

239 (183–270)

240 (198–291)

14

0.93

Gas exchange

 PaO2/FIO2, mmHg

137.5 ± 36.3

158.4 ± 35.9

163.8 ± 46.1

15

 < 0.01

 PaCO2, mmHg

63 (58–75)

64 (52–71)

63 (55–81)

15

0.08

 pH

7.28 ± 0.1

7.28 ± 0.11

7.27 ± 0.1

15

0.61

 SpO2 (%)

96 (95–98)

98 (96–99)

98 (96–99)

15

0.05

 PaCO2–ETCO2

15.8 ± 12.1

15.4 ± 13.4

15.8 ± 12.9

15

0.9

Hemodynamics

 Heart rate, beats/minute

92 ± 18

90 ± 17

90 ± 18

15

0.64

 Systolic arterial pressure, mmHg

127 ± 16

124 ± 19

123 ± 19

15

0.76

 Diastolic arterial pressure, mmHg

68 ± 8

68 ± 11

69 ± 8

15

0.91

 Mean arterial pressure, mmHg

88 ± 10

87 ± 13

88 ± 11

15

0.89

  1. BMI: body mass index; PBW: predicted body weight. PEEP: positive end-expiratory pressure; PaO2/FIO2: partial pressure of oxygen in arterial blood/inspired oxygen fraction ratio; PaCO2: partial pressure of carbon dioxide in arterial blood; SpO2: oxygen saturation; ETCO2: end-tidal CO2; n: number of patients
  2. Continuous variables are shown as mean ± SD or median (IQR) based on their distribution. Mixed model was used to compare the periods in supine position