Demographic data | |
---|---|
Number of patients, n | 15 |
Age, years | 53 (50–62) |
Male, n (%) | 14 (93) |
BMI, kg/m2 | 27 (24–29) |
APACHE II, Score | 13 (11–16) |
Recruitment-to-Inflation Ratio > 0.5, n (%) | 8 (53) |
Number of days from the symptom’s onset to intubation | 14 (11–16) |
Ventilation days before enrollment | 0.8 (0.3–2.1) |
Death in the ICU, n (%) | 6 (40) |
Sequential steps | |||||
---|---|---|---|---|---|
Supine-1 | Supine-2 | Supine-3 | N | p | |
Respiratory parameters | |||||
Driving airway pressure, cmH2O | 12.5 ± 2.4 | 11.6 ± 2.2 | 11.2 ± 2.1 | 15 | < 0.01 |
Respiratory system compliance, mL/cmH2O | 28.5 ± 8.5 | 30.6 ± 8.1 | 31.6 ± 8.4 | 15 | < 0.01 |
Plateau airway pressure, cmH2O | 26.8 ± 2.9 | 25.9 ± 2.7 | 25.6 ± 2.5 | 15 | < 0.01 |
Peak airway pressure, cmH2O | 32.4 ± 3.1 | 31.8 ± 3.3 | 31.3 ± 2.8 | 15 | < 0.01 |
Mean airway pressure, cmH2O | 19.3 ± 1.8 | 19.1 ± 1.8 | 19.0 ± 1.7 | 15 | < 0.05 |
Tidal volume, mL/kg | 5.4 ± 0.6 | 5.4 ± 0.6 | 5.4 ± 0.6 | 15 | 0.11 |
Expiratory minute volume, L/min | 8.5 ± 1.1 | 8.6 ± 1.1 | 8.6 ± 1.1 | 15 | 0.12 |
Total PEEP, cmH2O | 15.5 (12.5–15.8) | 15.4 (12.4–16.1) | 15.7 (12.7–15.9) | 15 | 0.55 |
Resistance, cmH2O/L/min | 10.8 ± 1.9 | 11.3 ± 2.1 | 11.0 ± 2.0 | 15 | 0.38 |
Driving transpulmonary pressure, cmH2O | 10.9 ± 2.5 | 10.2 ± 2.3 | 9.7 ± 2.1 | 14 | < 0.01 |
Lung compliance, mL/cmH2O | 33.8 ± 10.9 | 35.7 ± 10.5 | 37.5 ± 10.5 | 14 | 0.01 |
Inspiratory transpulmonary pressure, cmH2O | 15.9 ± 4.7 | 15.1 ± 4.5 | 14.7 ± 3.7 | 14 | 0.08 |
Expiratory transpulmonary pressure, cmH2O | 5.0 ± 3.6 | 4.9 ± 4.1 | 5.1 ± 3.1 | 14 | 0.8 |
Chest wall compliance, mL/cmH2O | 245 (188–262) | 239 (183–270) | 240 (198–291) | 14 | 0.93 |
Gas exchange | |||||
PaO2/FIO2, mmHg | 137.5 ± 36.3 | 158.4 ± 35.9 | 163.8 ± 46.1 | 15 | < 0.01 |
PaCO2, mmHg | 63 (58–75) | 64 (52–71) | 63 (55–81) | 15 | 0.08 |
pH | 7.28 ± 0.1 | 7.28 ± 0.11 | 7.27 ± 0.1 | 15 | 0.61 |
SpO2 (%) | 96 (95–98) | 98 (96–99) | 98 (96–99) | 15 | 0.05 |
PaCO2–ETCO2 | 15.8 ± 12.1 | 15.4 ± 13.4 | 15.8 ± 12.9 | 15 | 0.9 |
Hemodynamics | |||||
Heart rate, beats/minute | 92 ± 18 | 90 ± 17 | 90 ± 18 | 15 | 0.64 |
Systolic arterial pressure, mmHg | 127 ± 16 | 124 ± 19 | 123 ± 19 | 15 | 0.76 |
Diastolic arterial pressure, mmHg | 68 ± 8 | 68 ± 11 | 69 ± 8 | 15 | 0.91 |
Mean arterial pressure, mmHg | 88 ± 10 | 87 ± 13 | 88 ± 11 | 15 | 0.89 |