Variables | Derivation cohort (n = 194) | Validation cohort (n = 185) | p value |
---|---|---|---|
Baseline characteristics | |||
Age (year) | 61 (50, 71) | 60 (49, 74) | 0.773 |
Female gender | 117 (60.3) | 122 (65.9) | 0.239 |
BMI (kg/m2) | 19.9 (17.3, 21.3) | 20.7 (17.7, 22.1) | 0.603 |
APACHE II score | 15 (10, 18) | 14 (10, 18) | 0.228 |
Nonrenal SOFA score | 5 (1, 8) | 5 (2, 8) | 0.543 |
Baseline serum creatinine (μmol/L) | 63.8 (53.5, 73.3) | 65.4 (50.4, 73.2) | 0.617 |
Admission type | |||
Medical | 30 (15.5) | 27 (14.6) | 0.732 |
Surgical (abdominal surgery) | 93 (47.8) | 86 (46.5) | 0.892 |
Surgical (non-abdominal surgery) | 55 (28.4) | 52 (28.1) | 0.945 |
Emergency | 16 (8.3) | 20 (10.8) | 0.634 |
Main reason for admission | |||
Respiratory system | 59 (30.4) | 58 (32.4) | 0.624 |
Circulatory system | 65 (33.5) | 59 (31.9) | 0.710 |
Digestive system | 42 (21.6) | 43 (23.2) | 0.547 |
Urinary system | 17 (8.8) | 17 (9.2) | 0.812 |
Others | 11 (5.7) | 8 (4.3) | 0.634 |
Comorbidities | |||
COPD/asthma | 20 (10.3) | 20 (10.8) | 0.869 |
Cardiovascular disease | 40 (20.6) | 43 (23.2) | 0.536 |
Chronic liver disease | 42 (21.6) | 41 (22.2) | 0.902 |
Diabetes | 49 (25.2) | 40 (21.6) | 0.467 |
Hypertension | 91 (46.9) | 79 (42.7) | 0.469 |
CKD | 10 (5.1) | 7 (3.9) | 0.623 |
Sepsis | 89 (45.8) | 69 (37.3) | 0.102 |
Mechanical ventilation | 160 (82.5) | 151 (81.6) | 0.894 |
PaO2/FiO2 | 308.3 (232.5, 405.5) | 316.0 (216.0, 403.3) | 0.433 |
Use of vasopressor | 68 (35.1) | 61 (33.0) | 0.658 |
Use of diuresis | 28 (14.4) | 23 (12.4) | 0.724 |
AKI diagnosed by UO criteria | 65 (33.5) | 64 (34.6) | 0.812 |
AKI diagnosed by SCr criteria | 129 (66.5) | 121 (65.4) | 0.845 |
Serum creatinine diagnosing AKI (μmol/L) | 128.6 (86.2, 173.4) | 132.5 (90.4, 178.6) | 0.415 |
Peak serum creatinine (μmol/L) | 273.5 (154.6, 412.3) | 292.3 (174.6, 432.5) | 0.228 |
AKI classification | |||
Stage 1 | 104 (53.6) | 94 (38.7) | 0.588 |
2 | 58 (29.9) | 58 (44.0) | 0.526 |
3 | 32 (16.5) | 33 (17.8) | 0.713 |
Outcomes | |||
Renal recovery in 7 days | 115 (59.3) | 105 (56.8) | 0.677 |
Renal recovery at hospital discharge | 112 (57.7) | 103 (55.7) | 0.683 |
Need of RRT in ICU | 35 (18.1) | 30 (19.3) | 0.583 |
Hospital mortality | 33 (9.2) | 33 (8.6) | 0.893 |
30-day mortality | 34 (13.3) | 42 (12.9) | 0.393 |