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Table 5 Predictive accuracy of the biomarkers for non-recovery

From: Cell cycle arrest biomarkers for predicting renal recovery from acute kidney injury: a prospective validation study

  Cutoff value Sensitivity (%) Specificity (%) PPV (%) NPV (%)
[TIMP-2]*[IGFBP7] day 0 [(ng/mL)2/1000] 1.05 82.3 (67.4, 93.8) 76.9 (72.4, 88.5) 65.0 (43.2, 78.6) 88.5 (76.3, 95.8)
Clinical risk prediction model 0.436 77.1 (62.5, 92.3) 76.4 (60.2, 91.0) 67.5 (50.3, 81.4) 84.8 (65.3, 94.3)
[(TIMP-2)*(IGFBP7) day 0]—clinical risk prediction model 0.290 88.8 (72.9, 98.7) 86.2 (70.4, 97.3) 80.0 (65.9, 92.5) 92.6 (80.8, 100.0)
  1. TIMP-2 tissue inhibitor of metalloproteinases-2, IGFBP-7 insulin-like growth factor-binding protein 7, PPV positive predictive value, NPV negative predictive value