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Table 3 Follow-up parameters associated with DLCO alteration at 3 and 12 months

From: Result of one-year, prospective follow-up of intensive care unit survivors after SARS-CoV-2 pneumonia

 

3 months

12 months

 

Normal DLCO

N = 49

Altered DLCO

N = 36

p-value

Normal DLCO

N = 65

Altered DLCO

N = 8

p-value

6MWT

      

 Number evaluated

46 (93.9%)

33 (91.7%)

0.6948

59 (90.8%)

7 (87.5%)

0.5727

 Walked distance (m)

510 (450–570)

443 (370–525)

0.0199

540 (500–612)

545 (420–590)

0.4620

 Walked distance < theoretical distance (%)

23 (50.0%)

27 (81.8%)

0.0038

15 (25.4%)

3 (42.9%)

0.3800

Hospital Anxiety and Depression Scale

      

 Anxiety ≥ 11

6 (12.2%)

1 (2.8%)

0.2302

7 (10.8%)

0 (0.0%)

1

 Depression ≥ 11

2 (4.1%)

1 (2.8%)

1

3 (4.6%)

0 (0.0%)

1

MOS-SF36

      

 Physical functioning

80 (60–90)

65 (27.5–85)

0.0651

75 (65–90)

72.5 (60–82.5)

0.4695

 Role-physical

50 (0–100)

25 (0–87.5)

0.3489

100 (25–100)

75 (0–100)

0.3428

 Bodily pain

62 (42–84)

72 (50.5–84)

0.6144

62 (41–84)

63 (57–87)

0.5058

 Mental health

80 (60–92)

76 (64–90)

0.6822

76 (60–88)

86 (74–90)

0.3928

 Role-emotional

66.7 (0–100)

100 (0–100)

0.3206

100 (33.3–100)

83.3 (33.3–100)

0.9074

 Social functioning

75 (50–100)

68.8 (43.8–100)

0.5403

75 (50–100)

87.5 (81.3–100)

0.2072

 Vitality

55 (45–70)

55 (47.5–72)

1

60 (45–75)

57.5 (52.5–72.5)

0.8253

 General health

67 (57.82)

63.5 (54.5–72)

0.3808

67 (52–82)

58.5 (52–67)

0.5428

CT scan

      

 Missing data

5

0

 

9

0

 

 Abnormal scan

41 (93.2%)

36 (100%)

0.2481

56 (88.9%)

8 (100%)

1

  Reticulations

37 (90.2%)

32 (88.9%)

0.8458

52 (92.9%)

6 (75.0%)

0.5928

  Traction bronchiectasis

22 (53.7%)

31 (86.1%)

0.0029

38 (73.1%)

6 (75.0%)

1

  Honeycombing

2 (4.9%)

4 (11.1%)

0.4099

3 (5.8%)

0 (0.0%)

1

  Ground-glass opacity

29 (70.7%)

27 (75.0%)

0.6748

30 (57.7%)

2 (25.0%)

0.1300

  Emphysema

4 (9.8%)

10 (27.8%)

0.0408

6 (11.5%)

6 (75.0%)

0.0004

  1. Values are presented as medians (interquartile ranges) or number of patients (percentages)
  2. 6MWT  six-minute-walk test, MOS-SF36  medical outcomes study short form 36-item questionnaire, CT scan  computerized tomography scan