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Table 3 Follow-up parameters associated with DLCO alteration at 3 and 12 months

From: Result of one-year, prospective follow-up of intensive care unit survivors after SARS-CoV-2 pneumonia

  3 months 12 months
  Normal DLCO
N = 49
Altered DLCO
N = 36
p-value Normal DLCO
N = 65
Altered DLCO
N = 8
p-value
6MWT       
 Number evaluated 46 (93.9%) 33 (91.7%) 0.6948 59 (90.8%) 7 (87.5%) 0.5727
 Walked distance (m) 510 (450–570) 443 (370–525) 0.0199 540 (500–612) 545 (420–590) 0.4620
 Walked distance < theoretical distance (%) 23 (50.0%) 27 (81.8%) 0.0038 15 (25.4%) 3 (42.9%) 0.3800
Hospital Anxiety and Depression Scale       
 Anxiety ≥ 11 6 (12.2%) 1 (2.8%) 0.2302 7 (10.8%) 0 (0.0%) 1
 Depression ≥ 11 2 (4.1%) 1 (2.8%) 1 3 (4.6%) 0 (0.0%) 1
MOS-SF36       
 Physical functioning 80 (60–90) 65 (27.5–85) 0.0651 75 (65–90) 72.5 (60–82.5) 0.4695
 Role-physical 50 (0–100) 25 (0–87.5) 0.3489 100 (25–100) 75 (0–100) 0.3428
 Bodily pain 62 (42–84) 72 (50.5–84) 0.6144 62 (41–84) 63 (57–87) 0.5058
 Mental health 80 (60–92) 76 (64–90) 0.6822 76 (60–88) 86 (74–90) 0.3928
 Role-emotional 66.7 (0–100) 100 (0–100) 0.3206 100 (33.3–100) 83.3 (33.3–100) 0.9074
 Social functioning 75 (50–100) 68.8 (43.8–100) 0.5403 75 (50–100) 87.5 (81.3–100) 0.2072
 Vitality 55 (45–70) 55 (47.5–72) 1 60 (45–75) 57.5 (52.5–72.5) 0.8253
 General health 67 (57.82) 63.5 (54.5–72) 0.3808 67 (52–82) 58.5 (52–67) 0.5428
CT scan       
 Missing data 5 0   9 0  
 Abnormal scan 41 (93.2%) 36 (100%) 0.2481 56 (88.9%) 8 (100%) 1
  Reticulations 37 (90.2%) 32 (88.9%) 0.8458 52 (92.9%) 6 (75.0%) 0.5928
  Traction bronchiectasis 22 (53.7%) 31 (86.1%) 0.0029 38 (73.1%) 6 (75.0%) 1
  Honeycombing 2 (4.9%) 4 (11.1%) 0.4099 3 (5.8%) 0 (0.0%) 1
  Ground-glass opacity 29 (70.7%) 27 (75.0%) 0.6748 30 (57.7%) 2 (25.0%) 0.1300
  Emphysema 4 (9.8%) 10 (27.8%) 0.0408 6 (11.5%) 6 (75.0%) 0.0004
  1. Values are presented as medians (interquartile ranges) or number of patients (percentages)
  2. 6MWT  six-minute-walk test, MOS-SF36  medical outcomes study short form 36-item questionnaire, CT scan  computerized tomography scan