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Table 3 Changes in measurements of coagulation over duration of treatment

From: Effects of regional citrate anticoagulation on thrombin generation, fibrinolysis and platelet function in critically ill patients receiving continuous renal replacement therapy for acute kidney injury: a prospective study

  Baseline 12 h 24 h 36 h 48 h 72 h p value*
Haemoglobin (g/L) 102 (28) 95 (26) 93 (23) 91 (25) 91 (17) 87 (19) 0.017
Haematocrit 0.32 (0.09) 0.29 (0.08) 0.29 (0.07) 0.28 (0.08) 0.28 (0.06) 0.27 (0.06)  
Platelets (× 109/L) 233 (164) 187 (114) 176 (104) 173 (107) 174 (110) 169 (95) 0.043
INR
 Systemic 1.18 (0.15) 1.13 (0.13) 1.13 (0.13) 1.10 (0.11) 1.08 (0.10) 1.06 (0.09) 0.018
 Circuit   1.22 (0.15) 1.15 (0.13) 1.13 (0.11) 1.10 (0.10) 1.08 (0.12) 0.020
APTTr
 Systemic 1.29 (0.31) 1.25 (0.37) 1.18 (0.20) 1.11 (0.21) 1.11 (0.18) 1.17 (0.30) 0.077
 Circuit   1.33 (0.38) 1.23 (0.24) 1.17 (0.22) 1.20 (0.24) 1.19 (0.28) 0.262
Fibrinogen (g/L)
 Systemic 4.81 (1.47) 5.01 (1.67) 5.53 (1.85) 5.25 (1.74) 5.36 (1.64) 5.13 (1.80) 0.868
 Circuit   5.12 (1.70) 5.27 (2.07) 5.33 (1.86) 5.42 (1.58) 5.31 (1.93) 0.309
D-Dimer (mg/L)
 Systemic 15.8 (15.9) 13.4 (11.8) 16.2 (9.3) 14.4 (9.2) 13.8 (12.8) 15.5 (14.5) 0.984
 Circuit   15.4 (13.1) 15.2 (9.3) 13.4 (9.2) 15.1 (14.1) 15.6 (13.9) 0.912
TGA: maximum thrombin generation (nM)**
 Systemic 498.5 (390.6) 650.2 (383.8) 631.5 (397.7) 649.9 (443.9) 599.3 (290.3) 557.3 (315.1) 0.948
 Circuit   606.4 (422.9) 612.2 (349.7) 678.9 (458.3) 670.8 (249.0) 603.5 (187.6) 0.642
TGA: time to peak thrombin generation (min)**
 Systemic 22.9 (10.5) 21.5 (11.2) 26.3 (10.4) 21.7 (8.1) 28.7 (12.4) 31.1 (14.0) 0.186
 Circuit   22.7 (11.3) 27.6 (10.7) 21.3 (6.5) 23.2 (12.1) 25.9 (6.5) 0.668
PFSCA CT (s)***
 Systemic 127(80) 162 (92) 137 (82) 130 (45) 139 (84) 123 (74) 0.694
 Circuit   166 (94) 145 (72) 216 (84) 169 (89) 148 (74) 0.126
PFSCE CT (s)****
 Systemic 140 (85) 160 (77) 159 (75) 198 (69) 138 (36) 155 (73) 0.200
 Circuit   176 (87) 170 (82) 169 (80) 162 (64) 175 (68) 0.970
  1. INR International Normalised Ratio, APTTr activated partial thromboplastin time ratio, TGA thrombin generation assay, PFSCA platelet function assay using collagen/adenosine diphosphate, PFSCE platelet function assay using collagen/epinephrine, CT closure time
  2. *Repeated measures ANOVAs compared systemic parameters from baseline to 48 h. Post hoc pairwise comparisons found significant differences between haemoglobin at baseline and 36 h (p = 0.030) and baseline and 48 h (p = 0.018); platelets at baseline and 36 h (p = 0.035) and baseline and 48 h (p = 0.040) and INR at baseline and 36 h (p = 0.034) and baseline and 48 h (p = 0.024). There were no significant differences in systemic parameters on CRRT. Repeated measures ANOVAs of measurements from the circuit compared data from 12 to 48 h. Only INR differed overtime, with a significant difference between 12 and 48 h in post hoc comparisons (p = 0.002)
  3. **Test failed to return a result in 6.8% of samples (8/117)
  4. ***Test exceeded maximum permitted duration in 25.6% of samples (30/117); lower bound for duration of 300 s was used in analysis
  5. ****Test exceeded maximum permitted duration in 27.4% of samples (32/117), lower bound for duration of 300 s was used in analysis