Skip to main content

Table 4 Agreement between systemic and circuit measurements

From: Effects of regional citrate anticoagulation on thrombin generation, fibrinolysis and platelet function in critically ill patients receiving continuous renal replacement therapy for acute kidney injury: a prospective study

  Mean difference * 95% CI for mean difference SD difference Limits of agreement
  Lower limit Upper limit Lower limit Upper limit
INR − 0.03 − 0.05 − 0.01 0.05 − 0.13 0.07
APTTr − 0.07 − 0.13 − 0.02 0.18 0.42 0.28
Fibrinogen (g/L) − 0.06 − 0.22 0.09 0.51 − 1.06 0.93
D-Dimer (mg/L) − 4.5 − 0.15 0.21 2.4 − 5.2 4.2
TGA: maximum thrombin generation (nM) − 26.6 − 70.2 16.9 151.6 − 323.7 270.4
TGA: time to peak thrombin generation (mins) 2.1 − 0.4 4.6 8.5 − 14.5 18.7
PFSCA CT (s) − 28.8ρ − 53.4 − 4.2 86.6 − 198.5 140.9
PFSCE CT (s) − 7.4 − 29.5 14.7 77.7 − 159.7 145.0
  1. APTTr activated partial thromboplastin time ratio, INR International Normalised Ratio, TGA thrombin generation assay, PFSCA platelet function assay using collagen/adenosine diphosphate, PFSCE platelet function assay using collagen/epinephrine, CT closure time, CI confidence interval, SD standard deviation
  2. *Average difference between results of systemic samples and intra-circuit samples