Effects of regional citrate anticoagulation on thrombin generation, fibrinolysis and platelet function in critically ill patients receiving continuous renal replacement therapy for acute kidney injury: a prospective study

Annals of Intensive Care

Table 4 Agreement between systemic and circuit measurements

	Mean difference *	95% CI for mean difference		SD difference	Limits of agreement
	Mean difference *	Lower limit	Upper limit	SD difference	Lower limit	Upper limit
INR	− 0.03	− 0.05	− 0.01	0.05	− 0.13	0.07
APTTr	− 0.07	− 0.13	− 0.02	0.18	0.42	0.28
Fibrinogen (g/L)	− 0.06	− 0.22	0.09	0.51	− 1.06	0.93
D-Dimer (mg/L)	− 4.5	− 0.15	0.21	2.4	− 5.2	4.2
TGA: maximum thrombin generation (nM)	− 26.6	− 70.2	16.9	151.6	− 323.7	270.4
TGA: time to peak thrombin generation (mins)	2.1	− 0.4	4.6	8.5	− 14.5	18.7
PFSCA CT (s)	− 28.8ρ	− 53.4	− 4.2	86.6	− 198.5	140.9
PFSCE CT (s)	− 7.4	− 29.5	14.7	77.7	− 159.7	145.0

APTTr activated partial thromboplastin time ratio, INR International Normalised Ratio, TGA thrombin generation assay, PFSCA platelet function assay using collagen/adenosine diphosphate, PFSCE platelet function assay using collagen/epinephrine, CT closure time, CI confidence interval, SD standard deviation
^*Average difference between results of systemic samples and intra-circuit samples