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Fig. 2 | Annals of Intensive Care

Fig. 2

From: Loop diuretics in adult intensive care patients with fluid overload: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Fig. 2

Meta-analysis and TSA for all-cause mortality for loop diuretics vs. placebo/no intervention. a Meta-analysis. b TSA. The diversity adjusted required information size (DARIS) was calculated according to a mortality proportion in the control group (CEP) of 27%; risk ratio reduction (RRR) of 20% in the experimental intervention group; alpha of 1.7%; a beta of 10% (90% power); and diversity 0%. The DARIS was 3132 participants. The cumulative Z-curve (blue line) did not cross the trial sequential boundaries for benefit or harm or the inner-wedge futility line (red outward sloping red lines) nor the DARIS. The light blue dotted lines show naïve conventional boundaries (alpha 5%)

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