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Annals of Intensive Care
Fig. 3 | Annals of Intensive Care

Fig. 3

From: Loop diuretics in adult intensive care patients with fluid overload: a systematic review of randomised clinical trials with meta-analysis and trial sequential analysis

Fig. 3

Meta-analysis and TSA on highest event rate of SAEs for loop diuretics vs. placebo/no intervention. a Meta-analysis. b TSA. The diversity adjusted required information size (DARIS) was calculated according to the proportion of SAEs in the control group (CEP) of 47%; risk ratio reduction (RRR) of 20% in the experimental intervention group; alpha of 1.7%; a beta of 10% (90% power); and diversity 0%. The DARIS was 1372 participants. The cumulative Z-curve (blue line) did not cross the trial sequential boundaries for benefit or harm or the inner-wedge futility line (red outward sloping red lines) nor the DARIS. The light blue dotted lines show naïve conventional boundaries (alpha 5%)

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