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Table 2 Clinical course of the patients before and during COVID-19 pandemic

From: Comparison of clinical characteristics and hospital mortality in critically ill patients without COVID-19 before and during the COVID-19 pandemic: a multicenter, retrospective, propensity score-matched study

 

Total patients before propensity score matching

Propensity score matched patients

Before COVID-19 pandemic (n = 619)

During COVID-19 pandemic (n = 542)

p value

Before COVID-19 pandemic (n = 397)

During COVID-19 pandemic (n = 397)

p value

Organ support

 Mechanical ventilator (%)

261 (45.2)

303 (55.9)

 < 0.001

210 (52.9)

209 (52.6)

1.00

 Continuous renal replacement therapy (%)

118 (19.1)

125 (22.5)

0.096

90 (22.7)

89 (22.4)

1.00

 Extracorporeal membrane oxygenation (%)

14 (2.3)

18 (3.3)

0.286

11 (2.8)

15 (3.8)

0.551

Duration of hospitalization

 ER length of stay (hours)

(Mean ± SD, Median [IQR)])

8.70 ± 8.26

6.10 (4.11–9.58)

14.84 ± 13.30

10.21 (7.21–19.43)

 < 0.001

10.14 ± 9.44

6.90 (4.52–11.24)

12.13 ± 9.96

9.08 (6.49–14.22)

0.004

 ICU length of stay (days)

(Mean ± SD, Median [IQR)])

5.6 ± 7.7

4 (2–7)

8.0 ± 9.3

5 (2–10)

 < 0.001

6.6 ± 7.8

4 (2–8)

7.7 ± 9.0

5 (2–9)

0.060

 Hospital length of stay (days)

(Mean ± SD, Median [IQR])

15.8 ± 20.0

10 (4–19)

16.5 ± 16.7

12 (5–22)

0.044

16.7 ± 20.0

10 (4–22)

15.9 ± 16.0

11 (5–21)

0.589

Limitation of the treatment

 Do-Not-Resuscitation (DNR) order (%)

111 (17.9)

141 (26.0)

0.002

87 (21.9)

102 (25.7)

0.243

 Limitation of the treatment (%)*

81 (13.1)

111 (20.5)

0.001

57 (14.4)

76 (19.1)

0.087

 DNR in hopeless patient (%)

38 (6.1)

38 (7.0)

0.555

32 (8.1)

26 (6.5)

0.496

 ICU mortality (%)

154 (24.9)

199 (36.7)

 < 0.001

121 (30.5)

141 (35.5)

0.151

 Hospital mortality (%)

176 (28.4)

215 (39.7)

 < 0.001

131 (33.0)

152 (38.3)

0.138

  1. COVID, corona virus disease; ER, emergency room; SD, standard deviation; IQR, interquartile range; ICU, intensive care unit
  2. * The number of patient who refused intubation, renal replacement therapy, transfusion, vasoactive agent or chemotherapy