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Table 2 Echocardiography, biomarkers and clinical outcome in all patients and stratified by the presence of LV systolic function

From: Incidence of acute myocardial injury and its association with left and right ventricular systolic dysfunction in critically ill COVID-19 patients

 

All patients

LV systolic function

P value

n = 74

Normal

n = 38

Abnormal

n = 15

Echocardiography

Left ventricle

LVEF, %

62 (53–67.5)

64 (59–69.5)

47 (39–55)

<0.001

LVEF < 50%

8 (13.6%)

0 (0%)

8 (53.5%)

<0.001

LV s’, cm/sec

6 (5–7)

6 (6–8)

4 (4–5)

<0.001

MAPSE, mm

11 (9–13)

11 (11–14)

7 (6–9)

<0.001

GLS

−17 (−21 to −15)

−20 (−22 to −17)

−13 (−14 to −10)

< 0.001

VTI, cm

18.7 (15.4 to 21.9)

19.4 (16.4 to 22.5)

17 (11.6 to 21.7)

0.177

Right ventricle

TAPSE, mm

18 (16 to 22)

20.5 (18 to 23)

15 (12 to 17)

< 0.001

FAC, %

46 (39 to 53)

46 (41 to 54)

42 (33 to 48.5)

0.117

RVEDA:LVEDA

0.53 (0.46 to 0.57)

0.54 (0.46 to 0.57)

0.52 (0.45 to 0.57)

0.664

RV FWS

−23 (−27 to −21)

−25 (−29 to −21)

−23 (−25 to −16)

0.111

RV TV s’, cm/sec

10 (8 to 12)

11 (9 to 12)

7(6 to 9)

0.005

hsTnT max, ng/l

53 (21 to 127)

43 (16 to 105)

126 (50 to 284)

0.006

AMInj

60 (82%)

30 (78.9%)

14 (93.3%)

0.418

Vasopressor days

9.5 (5 to 21.25)

11.5 (6 to 23)

6 (4.5 to 13.5)

0.195

VIS, μg/kg/min

4.34 (1.94 to 7.31)

3.55 (1.5 to 6.69)

6.2 (3.64 to 7.73)

0.096

Proportion with IMV

69 (93%)

34 (90%)

14 (93%)

1

IMV days

14.5 (6.8 to 25.5)

15.5 (7 to 25)

16 (5 to 25.5)

0.737

SOFA max

10 (7.5 to 12)

9 (7 to 11)

10 (8 to 12)

0.304

ICU LOS, days

17 (8 to 27.5)

20 (11 to 32)

17 (6.5 to 26)

0.368

ICU mortality

14 (19%)

7 (18.4%)

2 (13.3%)

1

30-day mortality

13 (18%)

7 (18.4%)

2 (13.3%)

1

  1. P values refer to normal vs. abnormal systolic function
  2. LVEF left ventricular ejection fraction, MV s’ mitral valve tissue colour doppler systolic velocity (average of septal and lateral measurements), MAPSE mitral annular plane systolic excursion, GLS global longitudinal strain, VTI velocity time integral measured at the left ventricular outflow tract, TAPSE tricuspid annular plane systolic excursion, FAC fractional area contraction, EDA end diastolic area, FWS free wall strain, TV s’ tricuspid valve tissue colour doppler systolic velocity (free wall), hsTnT high sensitivity Troponin T, VIS vasopressor–inotrope score, IMV invasive mechanical ventilation. P values refer to normal vs. abnormal LV systolic function