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Table 2 Echocardiography, biomarkers and clinical outcome in all patients and stratified by the presence of LV systolic function

From: Incidence of acute myocardial injury and its association with left and right ventricular systolic dysfunction in critically ill COVID-19 patients

  All patients LV systolic function P value
n = 74 Normal
n = 38
Abnormal
n = 15
Echocardiography
Left ventricle
LVEF, % 62 (53–67.5) 64 (59–69.5) 47 (39–55) <0.001
LVEF < 50% 8 (13.6%) 0 (0%) 8 (53.5%) <0.001
LV s’, cm/sec 6 (5–7) 6 (6–8) 4 (4–5) <0.001
MAPSE, mm 11 (9–13) 11 (11–14) 7 (6–9) <0.001
GLS −17 (−21 to −15) −20 (−22 to −17) −13 (−14 to −10) < 0.001
VTI, cm 18.7 (15.4 to 21.9) 19.4 (16.4 to 22.5) 17 (11.6 to 21.7) 0.177
Right ventricle
TAPSE, mm 18 (16 to 22) 20.5 (18 to 23) 15 (12 to 17) < 0.001
FAC, % 46 (39 to 53) 46 (41 to 54) 42 (33 to 48.5) 0.117
RVEDA:LVEDA 0.53 (0.46 to 0.57) 0.54 (0.46 to 0.57) 0.52 (0.45 to 0.57) 0.664
RV FWS −23 (−27 to −21) −25 (−29 to −21) −23 (−25 to −16) 0.111
RV TV s’, cm/sec 10 (8 to 12) 11 (9 to 12) 7(6 to 9) 0.005
hsTnT max, ng/l 53 (21 to 127) 43 (16 to 105) 126 (50 to 284) 0.006
AMInj 60 (82%) 30 (78.9%) 14 (93.3%) 0.418
Vasopressor days 9.5 (5 to 21.25) 11.5 (6 to 23) 6 (4.5 to 13.5) 0.195
VIS, μg/kg/min 4.34 (1.94 to 7.31) 3.55 (1.5 to 6.69) 6.2 (3.64 to 7.73) 0.096
Proportion with IMV 69 (93%) 34 (90%) 14 (93%) 1
IMV days 14.5 (6.8 to 25.5) 15.5 (7 to 25) 16 (5 to 25.5) 0.737
SOFA max 10 (7.5 to 12) 9 (7 to 11) 10 (8 to 12) 0.304
ICU LOS, days 17 (8 to 27.5) 20 (11 to 32) 17 (6.5 to 26) 0.368
ICU mortality 14 (19%) 7 (18.4%) 2 (13.3%) 1
30-day mortality 13 (18%) 7 (18.4%) 2 (13.3%) 1
  1. P values refer to normal vs. abnormal systolic function
  2. LVEF left ventricular ejection fraction, MV s’ mitral valve tissue colour doppler systolic velocity (average of septal and lateral measurements), MAPSE mitral annular plane systolic excursion, GLS global longitudinal strain, VTI velocity time integral measured at the left ventricular outflow tract, TAPSE tricuspid annular plane systolic excursion, FAC fractional area contraction, EDA end diastolic area, FWS free wall strain, TV s’ tricuspid valve tissue colour doppler systolic velocity (free wall), hsTnT high sensitivity Troponin T, VIS vasopressor–inotrope score, IMV invasive mechanical ventilation. P values refer to normal vs. abnormal LV systolic function