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Table 3 Echocardiography, biomarkers and clinical outcome in all patients and stratified by the presence of RV systolic function

From: Incidence of acute myocardial injury and its association with left and right ventricular systolic dysfunction in critically ill COVID-19 patients

 

All patients

RV systolic function

P value

n = 74

Normal

n = 45

Abnormal

n = 13

Echocardiography

Left ventricle

LVEF, %

62 (53 to 67.5)

63 (57 to 70)

54 (50 to 63)

0.018

LVEF <50%

8 (13.6%)

4 (10.3%)

3 (25%)

0.334

LV s’, cm/sec

6 (5 to 7)

6 (4.9 to 6.93)

5 (4.77 to 7.41)

0.813

MAPSE, mm

10.75 (9 to 12.75)

11.25 (9.17 to 13.25)

8.88 (6 to 10.38)

0.004

GLS

−17 (−21 to −15)

−20 (−22 to −16)

−15 (−17 to −10)

0.022

VTI, cm

18.7 (15.4 to 21.9)

20.2 (15.7 to 23)

16 (12.3 to 17.9)

0.011

Right ventricle

TAPSE, mm

18 (16 to 22)

20 (18 to 23)

15 (13 to 16)

<0.001

FAC, %

46 (39 to 53)

45 (41 to 54)

47 (34 to 48)

0.267

RVEDA:LVEDA

0.53 (0.46 to 0.57)

0.52 (0.46 to 0.57)

0.56 (0.53 to 0.64)

0.050

RV FWS

−23 (−27 to −21)

−25 (−30 to −22)

−18 (−23 to −13)

<0.001

RV TV s’, cm/sec

9.8 (8 to 12)

10 (8 to 12.3)

9 (6 to 9.4)

0.018

hsTnT max, ng/l

53 (21 to 127)

47 (16 to 117)

85 (52 to 239)

0.026

AMInj

60 (82%)

34 (75.6%)

13 (100%)

0.055

Vasopressor days

9.5 (5 to 21.25)

9 (4 to 19)

17 (6 to 24)

0.201

VIS, μg/kg/min

4.34 (1.94 to 7.31)

3.78 (1.31 to 6.94)

4.36 (1.05 to 7.6)

0.929

Proportion requiring IMV

69 (93%)

34 (90%)

14 (93%)

1

IMV days

14.5 (6.8 to 25.5)

14 (6 to 24)

20 (12 to 28)

0.204

SOFA max

10 (7.5 to 12)

9 (7 to 11.5)

9 (8 to 12)

0.503

ICU LOS

17 (8 to 27.5)

18 (8 to 28)

21 (15 to 27)

0.526

ICU mortality

14 (19%)

9 (20%)

1 (7.7%)

1

30-day mortality

13 (18%)

7 (15.6%)

2 (15.4%)

1

  1. P values refer to normal vs. abnormal systolic function
  2. LVEF left ventricular ejection fraction, MV s’ mitral valve tissue colour doppler systolic velocity (average of septal and lateral measurements), MAPSE mitral annular plane systolic excursion, GLS global longitudinal strain, VTI velocity time integral measured at the left ventricular outflow tract, TAPSE tricuspid annular plane systolic excursion, FAC fractional area change, EDA end diastolic area, FWS free wall strain, TV s’ tricuspid valve tissue colour doppler systolic velocity (free wall), hsTnT high sensitivity Troponin T, VIS vasopressor–inotrope score, IMV invasive mechanical ventilation. P values refer to normal vs. abnormal RV systolic function