Table 5 Multivariable logistic regression analysis showing the association with major adverse kidney events within 30 days
From: Fluid accumulation and major adverse kidney events in sepsis: a multicenter observational study
Variable | Unadjusted odds ratio (95% CI) | p value | Adjusted odds ratioa (95% CI) | p value |
|---|---|---|---|---|
Cumulative fluid balance, litre | 1.08 (1.05–1.11) | < 0.001 | 1.05 (1.02–1.09) | 0.003 |
Age, year | 1.02 (1.01–1.03) | < 0.001 | 1.03 (1.02–1.04) | < 0.001 |
Male sex | 0.92 (0.75–1.13) | 0.41 | 0.86 (0.67–1.11) | 0.25 |
Body weight, kg | 0.99 (0.99–1.00) | 0.01 | 0.99 (0.99–1.00) | 0.09 |
Baseline creatinine, per 10 µmol/l | 1.00 (1.00–1.01) | 0.02 | 1.01 (1.00–1.02) | 0.03 |
Chronic liver disease | 2.21 (1.58–3.10) | < 0.001 | 1.86 (1.23–2.82) | 0.003 |
Chronic cardiac disease | 1.37 (1.06–1.78) | 0.02 | 1.32 (0.96–1.82) | 0.09 |
Chronic respiratory disease | 1.26 (0.93–1.73) | 0.14 | 1.19 (0.82–1.73) | 0.35 |
Immune deficiency | 1.71 (1.39–2.12) | < 0.001 | 1.62 (1.25–2.10) | < 0.001 |
Duration with MAP < 65 mmHg | ||||
< 5 h | 1.00 | 1.00 | ||
5–10 h | 0.90 (0.68–1.18) | 0.44 | 0.74 (0.54–1.01) | 0.06 |
> 10 h | 1.16 (0.92–1.46) | 0.21 | 0.86 (0.66–1.13) | 0.29 |
Vancomycin therapy | 1.51 (1.04–2.18) | 0.03 | 1.75 (1.12–2.74) | 0.01 |
Aminoglycoside therapy | 1.00 (0.78–1.31) | 0.95 | 0.88 (0.65–1.20) | 0.42 |
Hydroxyethyl starch administration | 0.95 (0.72–1.26) | 0.74 | 0.96 (0.66–1.38) | 0.81 |
Highest C-reactive protein, mg/l | 1.00 (1.00–1.00) | 0.23 | 1.00 (1.00–1.00) | 0.44 |
Highest chloride level | ||||
< 108 mmol/l | 1.00 | 1.00 | ||
108–111 mmol/l | 0.88 (0.68–1.15) | 0.36 | 0.90 (0.66–1.23) | 0.51 |
> 111 mmol/l | 0.82 (0.64–1.06) | 0.13 | 0.76 (0.56–1.04) | 0.08 |
Highest lactate level | ||||
< 2 mmol/l | 1.00 | 1.00 | ||
≥ 2 mmol/l | 1.46 (1.13–1.89) | 0.004 | 1.05 (0.76–1.45) | 0.77 |
Highest bilirubin level | ||||
< 20 µmol/l | 1.00 | 1.00 | ||
20–32 µmol/l | 1.24 (0.95–1.62) | 0.11 | 1.03 (0.76–1.39) | 0.84 |
> 32 µmol/l | 1.79 (1.40–2.29) | < 0.001 | 1.31 (0.97–1.75) | 0.08 |
Lowest platelet count | ||||
≥ 150 | 1.00 | 1.00 | ||
100–149 | 1.50 (1.14–1.99) | 0.004 | 1.60 (1.16–2.21) | 0.004 |
< 100 | 2.21 (1.75–2.80) | < 0.001 | 2.05 (1.53–2.74) | < 0.001 |
Invasive mechanical ventilation | 1.37 (1.12–1.69) | 0.003 | 1.69 (1.31–2.19) | < 0.001 |