Impact on 6-month outcomes of hospital trajectory in critically ill older patients: analysis of the ICE-CUB2 clinical trial

Annals of Intensive Care

Table 3 Multivariate analysis of factors associated with mortality or loss of one-point ADL at 6 months

Variables	Odds ratio (95% CI)^a	p value
Hospital destination (ref IMCU)
AMW	1.05 (0.99–1.11)	0.096
ICU	1.05 (0.99–1.11)	0.105
Age (per one-point increase)	1.01 (1.01–1.02)	< 0.001
Male sex (vs female)	0.98 (0.95–1.02)	0.405
Presence of comorbidities	1.04 (1.00–1.09)	0.041
SAPS-3 (per one-point increase)	1.01 (1.01–1.01)	< 0.001
ADL (per one-point decrease)	1.04 (1.01–1.07)	0.007
Admission diagnosis (ref: cardiac disorder)
Surgery	0.98 (0.85–1.13)	0.754
Coma	1.1 (1.01–1.19)	0.025
Respiratory failure	0.99 (0.93–1.05)	0.721
Gastrointestinal tract disorder	0.94 (0.85–1.04)	0.206
Shock	0.91 (0.85–0.98)	0.011
Multiple trauma with no surgery	0.90 (0.71–1.14)	0.373
Acute kidney injury	0.96 (0.87–1.05)	0.369
Other	0.91 (0.84–0.98)	0.009

Multivariate analysis using logistic regression model
95% CI: 95% confidence interval, ADL: Activity of daily living, ICU: intensive care unit, IMCU: intermediate care unit, OR: odds ratio, ref: reference, SAPS-3: Simplified Acute Physiology Score 3
^aOR gives the factors associated with overall 6-month mortality or loss of 1-point ADL per each unit increase for continuous variables and for one specific category vs a reference category for categorical variables