Impact of early mean arterial pressure level on severe acute kidney injury occurrence after out-of-hospital cardiac arrest

Dupont, Vincent; Bonnet-Lebrun, Anne-Sophie; Boileve, Alice; Charpentier, Julien; Mira, Jean-Paul; Geri, Guillaume; Cariou, Alain; Jozwiak, Mathieu

doi:10.1186/s13613-022-01045-1

Annals of Intensive Care

Table 2 Association between mean arterial pressure level and severe acute kidney injury occurrence: summary of the different regression models

From: Impact of early mean arterial pressure level on severe acute kidney injury occurrence after out-of-hospital cardiac arrest

Variables	All patients (n = 568)	Severe AKI		Univariate analysis		Multivariate analysis
Variables	All patients (n = 568)	No (n = 294)	Yes (n = 274)	Unadjusted OR [95% CI]	p value	Adjusted OR [95% CI]	p value
First 6 h
Mean MAP value, mmHg	91 ± 14	94 ± 14	88 ± 14	0.99 [0.95–0.98]	< 0.01	1.00 [0.98–1.02]	0.93
ABT MAP < 65 mmHg, 10² mmHg-h	0.7 ± 0.2	0.3 ± 1.1	1.2 ± 3.0	1.34[1.16–1.54]	< 0.01	1.69 [1.26–2.26]	< 0.01
ABT MAP < 75 mmHg, 10² mmHg-h	3.2 ± 6.5	1.8 ± 4.4	4.6 ± 7.9	1.09 [1.05–1.13]	< 0.01	1.13 [1.07–1.20]	< 0.01
ABT MAP < 85 mmHg, 10² mmHg-h	9.2 ± 14.5	6.2 ± 11.6	12.3 ± 16.5	1.03 [1.02–1.05]	< 0.01	1.04 [1.02–1.06]	< 0.01
Percentage time MAP < 65 mmHg, 10%	0.9 ± 1.8	0.6 ± 1.4	1.3 ± 2.0	1.26 [1.15–1.38]	< 0.01	1.19 [1.06–1.33]	< 0.01
Percentage time MAP < 75 mmHg, 10%	2.4 ± 3.0	1.7 ± 2.7	3.1 ± 3.1	1.23 [1.10–1.16]	< 0.01	1.12 [1.04–1.19]	< 0.01
Percentage time MAP < 85 mmHg, 10%	4.2 ± 3.5	3.5 ± 3.5	4.9 ± 3.4	1.11 [1.06–1.16]	< 0.01	1.08 [1.02–1.14]	< 0.01
First 12 h
Mean MAP value, mmHg	88 ± 12	90 ± 12	85 ± 12	0.96 [0.94–0.98]	< 0.01	1.01 [0.99–1.03]	0.50
ABT MAP < 65 mmHg, 10² mmHg-h	1.6 ± 10.6	0.4 ± 1.6	2.8 ± 15.1	1.28 [1.14–1.43]	< 0.01	1.48 [1.21–1.81]	< 0.01
ABT MAP < 75 mmHg, 10² mmHg-h	6.5 ± 21.1	2.9 ± 7.5	10.3 ± 28.9	1.05 [1.03–1.08]	< 0.01	1.07 [1.04–1.10]	< 0.01
ABT MAP < 85 mmHg, 10² mmHg-h	18.2 ± 34.6	10.9 ± 21.0	26.1 ± 43.6	1.02 [1.01–1.03]	< 0.01	1.02 [1.01–1.03]	< 0.01
Percentage time MAP < 65 mmHg, 10%	0.9 ± 1.8	0.5 ± 1.4	1.3 ± 2.0	1.32 [1.19–1.44]	< 0.01	1.23 [1.09–1.37]	< 0.01
Percentage time MAP < 75 mmHg, 10%	2.5 ± 2.9	1.8 ± 2.6	3.2 ± 3.0	1.18 [1.12–1.25]	< 0.01	1.14 [1.06–1.22]	< 0.01
Percentage time MAP < 85 mmHg, 10%	4.3 ± 3.5	3.7 ± 3.5	5.1 ± 3.4	1.12 [1.07–1.16]	< 0.01	1.08 [1.02–1.14]	< 0.01

Variables are expressed as mean ± standard deviation. All logistic regression models included one of the MAP-derived variables (percentage time spent under the MAP threshold or ABT in each model), age, gender, witness attendance, initial rhythm, epinephrine use during resuscitation, resuscitation durations admission creatinine level, history of arterial hypertension and median norepinephrine dosage
AKI acute kidney injury, ABT area below threshold, CI confidence interval, MAP mean arterial pressure

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