Skip to main content
Annals of Intensive Care

Table 3 Ventilation data, sedation, opioids, NMBA use and tracheostomy data

From: Early prediction of hospital outcomes in patients tracheostomized for complex mechanical ventilation weaning

 

Study population

Favourable outcome

Poor outcome

 
 

N = 80*

N = 50*

N = 30*

p value#

Ventilation data between intubation and tracheostomy

   

 Percentage of mechanical ventilation days with more than 12 h with:

    

  VAC, n. (%)

33.3% [18–59%]

39.3% [22–60%]

28.7% [10–48%]

0.16

  PAC, n. (%)

0% [0–0%]

0% [0–0%]

0% [0–0%]

0.85

  PSV, n. (%)

61.1% [40–79%]

57.7% [40–74%]

66.7% [46–86%]

0.22

  Other, n. (%)

0% [0–0%]

0% [0–0%]

0% [0–0%]

0.55

 VT, mL

454.6 [414–530]

441.2 [403–532]

469.5 [424–533]

0.29

 VT/PBW, mL/kg

7 [6–8]

7 [6–8]

7 [6–8]

0.57

 PEEP, cmH2O

6.9 [6–8]

6.8 [6–8]

7.1 [6–8]

0.10

 RR, cycle/min

21.8 [20–25]

22.6 [20–25]

21.5 [18–26]

0.94

 Dynamic Pplat, cmH2O

20.3 [18–24]

21.7 [18–25]

20 [17–22]

0.10

 Driving pressure, cmH2O

13.4 [11–15]

13.9 [12–17]

12.2 [10–14]

0.04

 Separation attempts

   

0.57

  0

21 (26.3%)

11 (22%)

10 (33.3%)

 

  1

11 (13.8%)

8 (16%)

3 (10%)

 

  2

11 (13.8%)

6 (12%)

5 (16.7%)

 

  > 2

37 (46.3%)

25 (50%)

12 (40%)

 

Percentage of days with sedation use

   

 Any sedation, %

93.5% [76–100%]

100% [79–100%]

89.3% [66–100%]

0.09

 Propofol, %

74.3% [50–91%]

77.8% [55–95%]

69% [49–86%]

0.29

 Midazolam, %

19.1% [0–53%]

33.3% [9–54%]

12.9% [0–34%]

0.06

 Dexmedetomidine, %

0% [0–21%]

9.8% [0–25%]

0% [0–13%]

0.11

Percentage of days with opioids use

  

 Opioids, %

100% [87–100%]

100% [89–100%]

100% [77–100%]

0.77

 Morphine, %

0% [0–0%]

0% [0–0%]

0% [0–2%]

0.30

 Fentanyl, %

94.2% [67–100%]

93.8% [72–100%]

96.1% [53–100%]

0.88

 Other opioids, %

0% [0–0%]

0% [0–0%]

0% [0–0%]

0.80

Percentage of days with NMBA use

    

 NMBA, %

12.5% [0–30%]

14.4% [4–31%]

10.4% [0–28%]

0.40

Proportion of patients receiving sedation or opioids the day before tracheostomy

   

 Sedation, n (%)

60 (75.0%)

38 (76%)

22 (73.3%)

0.80

 Opioids n (%)

67 (83.75%)

43 (86%)

24 (80%)

0.54

Tracheostomy data

    

 Worst PaO2/FiO2 ratio on the day of tracheostomy

   

0.50

  ≥ 400 mmHg

2 (2.5%)

1 (2%)

1 (3.3%)

 

  < 400 mmHg

12 (15%)

5 (10%)

7 (23.3%)

 

  < 300 mmHg

18 (22.5%)

13 (26%)

5 (16.7%)

 

  < 200 mmHg

43 (53.8%)

28 (56%)

15 (50%)

 

  < 100 mmHg

5 (6.3%)

3 (6%)

2 (6.7%)

 

 Type of tracheostomy

   

0.76

  Percutaneous, n (%)

13 (16.25%)

9 (18%)

4 (13. 3%)

 

  Surgical, n (%)

67 (83.75%)

41 (82%)

26 (86. 7%)

 

 Time from intubation to tracheostomy, days

14.7 [10–20]

14.6 [10–20]

14.8 [10–22]

0.92

  1. N = 80 except for dynamic Pplat and driving pressure, where N = 70 (N = 45 for favourable outcome and N = 25 for poor outcome)
  2. VAC volume assist-control, PSV pressure-support ventilation, PAC pressure assist-control ventilation, VT tidal volume, PBW predicted body-weight, PEEP positive end-expiratory pressure, RR respiratory rate, Pplat plateau pressure, NMBA neuromuscular blocking agents, VT, VT/PBW, PEEP, RR and Dynamic Pplat were recorded once a day at 8 am
  3. #p value calculated using T test or Mann–Whitney test for continuous data and Fisher’s exact test for categorical data
Back to article page