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Table 2 Parameters of the REALIST score and their predictive power of secondary infection at day 30

From: A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score

  Cutoff AUC Specificity (95% CI) Sensitivity (95% CI) PPV (95% CI) NPV (95% CI) HR (95% CI)
mHLA-DR  ≤ 7627 Ab/C 0.71 0.63
(0.46–0.79)
0.73
(0.53–0.9)
0.27
(0.22–0.38)
0.92
(0.89–0.96)
2.52
(1.31–4.85)
Immature neutrophils  ≥ 23.5% 0.71 0.72
(0.57–0.81)
0.7
(0.53–0.83)
0.32
(0.24–0.41)
0.93
(0.89–0.96)
2.55
(1.38–4.73)
IL-10  ≥ 8.5 pg/ml 0.60 0.53
(0.43–0.69)
0.73
(0.53–0.87)
0.23
(0.19–0.29)
0.91
(0.87–0.96)
2.18
(1.07–4.45)
  1. As measured in the cohort of interest (n = 189 ICU patients at days 5–7)
  2. Values are presented with 95% confidence interval (CI)
  3. AUC area under the curve, PPV positive predictive value, NPV negative predictive value