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Table 2 Parameters of the REALIST score and their predictive power of secondary infection at day 30

From: A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score

 

Cutoff

AUC

Specificity (95% CI)

Sensitivity (95% CI)

PPV (95% CI)

NPV (95% CI)

HR (95% CI)

mHLA-DR

 ≤ 7627 Ab/C

0.71

0.63

(0.46–0.79)

0.73

(0.53–0.9)

0.27

(0.22–0.38)

0.92

(0.89–0.96)

2.52

(1.31–4.85)

Immature neutrophils

 ≥ 23.5%

0.71

0.72

(0.57–0.81)

0.7

(0.53–0.83)

0.32

(0.24–0.41)

0.93

(0.89–0.96)

2.55

(1.38–4.73)

IL-10

 ≥ 8.5 pg/ml

0.60

0.53

(0.43–0.69)

0.73

(0.53–0.87)

0.23

(0.19–0.29)

0.91

(0.87–0.96)

2.18

(1.07–4.45)

  1. As measured in the cohort of interest (n = 189 ICU patients at days 5–7)
  2. Values are presented with 95% confidence interval (CI)
  3. AUC area under the curve, PPV positive predictive value, NPV negative predictive value