Effects of mean arterial pressure target on mottling and arterial lactate normalization in patients with septic shock: a post hoc analysis of the SEPSISPAM randomized trial

Annals of Intensive Care

Table 2 Univariate and multivariate analysis evaluating the impact of the course of mottling on day 90 mortality in septic shock

Duration of mottling within the first 24 h	Univariate analysis n = 747		Multivariate analysis^† n = 656
Duration of mottling within the first 24 h	HR	p-value	HR	p-value
No mottling (reference)	1	–	1	–
1–5 h	1.24 [0.79–1.92]	0.35	1.03 [0.62–1.72]	0.91
6–24 h	3.32 [2.64–4.18]	< 0.001	2.14 [1.63–2.81]	< 0.001
1–5 h (reference)	1	–	1	–
6–24 h	2.69 [1.73–4.17]	< 0.001	2.08 [1.25–3.46]	0.005

^†Multivariate analysis based on the randomization group (low-MAP or high-MAP target), lactate at inclusion, age, SAPS II, history of chronic arterial hypertension, history of ischemic heart disease, and MAP, fluid intake, vasopressor dose and need for mechanical ventilation at inclusion. We did not include the pH, SOFA, acute kidney injury or PaO₂/FiO₂ ratio for competing with other variables. Ninety-one patients were excluded because of missing data on at least 1 adjustment variable