Table 2 Cefoxitin TDM and PK modeling
Variables | Median [IQR] or counts (%) |
|---|---|
TDM—measured cefoxitin serum concentrations | |
Delay between cefoxitin bolus and first TDM—h | 19 [13–24] |
Total serum cefoxitin concentration measured at 1st TDM—mg/L | 37 [22–72] |
Number of TDM occurrences per patient | |
1 | 18 (44%) |
2 | 15 (36%) |
3 | 8 (20%) |
Model-based cefoxitin serum concentrations 24 h after bolus | |
Total serum cefoxitin concentration—mg/L | 43 [23–72] |
Patients with fT>MIC = 100% | 34 (83%) |
Patients with fT>MIC ECOFF = 100% | 19 (36%) |