Fig. 1

Study flowchart. *Mostly due to inclusion in SICS before sub-study started or not eligible for CCE in SICS-II. ⁺The predefined requirements were: a stable echocardiogram (ECG), an apical four-chamber view (AP4CH) with the myocardial wall clearly visualized and defined, a maximum angle deviation of 15 degrees between the segment of interest and the contraction axis to limit errors caused by angle deviation and a frame rate of at least 160 frames per second for optimal offline strain analysis