Table 1 Patient characteristics including clinically relevant features used for prediction
Parameter | Missing (%) | Values | Units |
|---|---|---|---|
Number of prone events | Â | 3619 | Â |
Number of patients | Â | 1142 | Â |
Prone events per patient, median [Q1, Q3] | Â | 2 [1, 4] | Â |
Age, median [Q1,Q3] | 0.0 | 66.0 [58.0,72.0] | Years |
Gender, female, n (%) | 0.0 | 944 (26.1) | Â |
BMI, median [Q1,Q3] | 0.0 | 27.2 [24.6,30.0] | |
Comorbidities | Â | Â | |
Chronic dialysis, n (%) | 30.0 | 43 (1.7) | Â |
Chronic renal insufficiency, n (%) | 30.0 | 256 (10.1) | Â |
Cirrhosis, n (%) | 30.0 | 103 (4.1) | Â |
COPD, n (%) | 30.0 | 349 (13.8) | Â |
Diabetes, n (%) | 30.0 | 613 (24.2) | Â |
Neoplasm, n (%) | 30.0 | 132 (5.2) | Â |
Hematologic malignancy, n (%) | 30.0 | 193 (7.6) | Â |
Immune insufficiency, n (%) | 30.0 | 356 (14.1) | Â |
Respiratory insufficiency, n (%) | 30.0 | 196 (7.7) | Â |
Cardiovascular insufficiency, n (%) | 30.0 | 131 (5.2) | Â |
Clinical measurements, average | Â | ||
etCO2 2Â h, mean (SD) | 14.6 | 41.3 (11.0) | mmHg |
paCO2-etCO2 2Â h, mean (SD) | 27.5 | 13.3 (10.9) | mmHg |
FiO2 2Â h, mean (SD) | 3.3 | 65.6 (17.6) | % |
Peak airway pressure 2Â h, mean (SD) | 10.3 | 27.2 (6.2) | cmH2O |
Delta pressure 2Â h, mean (SD) | 20.3 | 13.5 (5.4) | cmH2O |
PEEP 2Â h, mean (SD) | 8.1 | 12.2 (3.3) | cmH2O |
Respiratory system compliance 2Â h, mean (SD) | 10.2 | 43.6 (31.0) | ml/cmH2O |
Tidal volume per kg 2Â h, mean (SD) | 8.2 | 6.7 (1.5) | ml/kg |
Respiratory rate 2Â h, mean (SD) | 1.5 | 24.7 (5.5) | /min |
Minute volume 2Â h, mean (SD) | 8.3 | 11.0 (3.0) | ml/min |
PaO2/FiO2 ratio 2Â h, mean (SD) | 20.4 | 120.5 (45.4) | mmHg |
Ventilatory ratio 2Â h, mean (SD) | 12.6 | 2.3 (0.9) | Â |
Mechanical power 2Â h, mean (SD) | 12.5 | 32.9 (14.3) | J/min |
Mean arterial blood pressure 2Â h, mean (SD) | 3.2 | 78.7 (12.5) | mmHg |
Heart rate 2Â h, mean (SD) | 5.9 | 88.5 (19.6) | /min |
CRP 2Â h, mean (SD) | 21.0 | 199.2 (123.8) | mg/l |
Leukocytes 2Â h, mean (SD) | 6.5 | 11.5 (5.5) | 109/l |
Thrombocytes 2Â h, mean (SD) | 4.8 | 304.9 (135.1) | 109/l |
d-dimer 2Â h, mean (SD) | 57.7 | 3061.2 (2251.5) | ng/ml |
Lactate arterial 2Â h, mean (SD) | 44.0 | 1.3 (0.6) | mmol/l |
pO2 arterial 2Â h, mean (SD) | 19.5 | 69.7 (10.2) | mmHg |
pCO2 arterial 2Â h, mean (SD) | 6.8 | 53.9 (14.3) | mmHg |
pH arterial 2Â h, mean (SD) | 24.8 | 7.4 (0.1) | Â |
Creatinine 2 h, mean (SD) | 6.0 | 115.8 (105.2) | µmol/l |
Clinical measurements, slopes | Â | ||
Last FiO2 2 h slope, median [Q1,Q3] | 13.5 | 0.0 [− 5.0,2.5] | %/h |
PaO2/FiO2 ratio 8 h slope, median [Q1,Q3] | 80.2 | 1.0 [− 1.7,3.7] | mmHg/h |
Ventilatory ratio 8 h slope, median [Q1,Q3] | 47.6 | − 0.0 [− 0.0,0.0] | /h |
Mechanical power 8 h slope, median [Q1,Q3] | 32.0 | 0.0 [− 0.6,0.6] | J/min/h |
Outcomes | Â | ||
PaO2/FiO2 ratio 3Â h last, median [Q1,Q3] | 18.3 | 111.6 [86.8,141.7] | |
Ventilatory ratio 3Â h last, median [Q1,Q3] | 32.2 | 2.2 [1.7,2.9] | |
Mechanical power 3Â h last, median [Q1,Q3] | 23.5 | 32.0 [20.9,44.7] | J/min |
Respiratory system compliance 3Â h last, median [q1, q3] | 9.8 | 32.8 [24.4,48.5] | ml/cmH2O |
PaO2/FiO2 ratio difference, median [Q1, Q3] | 27.3 | 14.9 [− 5.3,40.5] | |
Ventilatory ratio difference, median [Q1, Q3] | 37.4 | 0.0 [− 0.3,0.4] | |
Mechanical power difference, median [Q1, Q3] | 26.7 | 0.2 [− 9.8,9.2] | J/min |
Respiratory system compliance difference, median [Q1, Q3] | 12.9 | − 0.6 [− 5.8,3.6] | ml/cmH2O |