Outcomes of mild-to-moderate postresuscitation shock after non-shockable cardiac arrest and association with temperature management: a post hoc analysis of HYPERION trial data

Annals of Intensive Care

Table 3 Characteristics of patients with postresuscitation shock (PRS) in the groups with favourable vs. unfavourable outcome^a

Characteristics	Favourable^a outcome (N = 24)	Unfavourable^a outcome (N = 315)	P value
Age, years, median [IQR]	62.5 [57.1–69.8]	67.6 [58.0–77.2]	0.085
Males, n (%)	19 (79.2)	191 (60.6)	0.072
Cardiac arrest location, n (%)			0.012
Home	6 (25.0)	163 (51.7)
Elsewhere	18 (75.0)	152 (48.3)
No-flow time, min, median [IQR]	0.0 [0.0–2.0]	2.0 [0.0–5.0]	0.012
Low-flow time, min, median [IQR]	10.0 [5.0–12.5]	20.0 [12.0–29.0]	< 0.0001
Arterial pH, median [IQR]	7.2 [7.0–7.3]	7.2 [7.1–7.3]	0.79
PCI, n (%)	1 (4.2)	25(7.9)	1.00
Total epinephrine dose, mg, n (%)			0.021
0	4 (17.4)	11 (3.5)
1 or 2	8 (34.8)	104 (33.3)
≥ 3	11 (47.8)	197 (63.1)
CAHP score, median [IQR]	171 [150–185]	196 [175–219]	0.0001
33° group^b, n (%)	14 (58.3)	145 (46.0)	0.24
GCS score, median [IQR]	3 [3–3]	3 [3–3]	0.58

PCI: percutaneous coronary intervention; CAHP: Cardiac Arrest Hospital Prognosis; GCS: Glasgow Coma Scale
^aFavourable outcome was defined as a Cerebral Performance Category score of 1 or 2 on day 90 and unfavourable outcome as a Cerebral Performance Category score of 3, 4, or 5 on day 90
^bIn the HYPERION trial used as the source of data for the present study, patients were allocated at random to treatment with hypothermia at 33 °C or normothermia at 37 °C