Variable | All patients N = 969 | Early dexamethasone N = 611 | No steroids N = 358 | P value |
---|---|---|---|---|
Day-28 mortality (primary outcome), n (%) | 143 (14.8) | 92 (15.1) | 51 (14.3) | 0.58a |
Secondary outcomes | ||||
Adverse events in the ICU, n (%) | ||||
Bloodstream infection | 87 (9.0) | 58 (9.5) | 29 (8.1) | 0.19b |
Ventilator-associated pneumonia | 277 (48.5) | 173 (52.9) | 104 (42.6) | 0.04b |
Invasive fungal infection | 43 (4.4) | 26 (4.3) | 17 (4.8) | 0.72c |
Gastrointestinal bleeding | 32 (3.3) | 24 (3.9) | 8 (2.2) | 0.16c |
Intubation in the ICU, n (%) | 450/848 (53.1) | 268/552 (48.6) | 182/296 (61.49) | < 0.001b |
Time from ICU admission to iMV, days, median [IQR] | 1.00 [0.00–2.00] | 1.00 [0.00–2.00] | 0.00 [0.00–1.00] | < 0.001d |
iMV-free days on day 28, median [IQR] | 20.0 [1.0–28.0] | 22.0 [2.0–28.0] | 17.0 [1.0–28.0] | < 0.003d |
Renal replacement therapy, n (%) | 77 (8.0) | 42 (6.9) | 35 (9.8) | 0.03b |
Alive and out of the ICU on day 28, n (%) | 652 (67.3) | 410 (67.1) | 242 (67.3) | 0.89e |
90-day mortality n (%) | 188 (19.4) | 126 (20.6) | 62 (17.3) | 0.16a |