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Annals of Intensive Care
Fig. 1 | Annals of Intensive Care

Fig. 1

From: Adverse outcomes with extracorporeal adsorbent blood treatments in toxic systemic inflammation: a perspective on possible mechanisms

Fig. 1

Stabilization and amplification of inflammatory mediator function. Enzyme A adsorption to matrix illustrates disrupted structure and a masked active site (AS) resulting in loss of function, i.e., the enzyme is totally neutralized. This is probably the fate of most enzymes adsorbed to matrix. Enzyme B adsorption to matrix illustrates stabilized structure and presentation of its AS in blood or plasma flow which could increase substrate binding events. Such enzyme function preservation or enhancement may be infrequent, but could be contrary to the therapeutic intention of adsorptive treatment

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