Table 2 Light-to-moderate sedation (< 3 mg/kg/h of propofol or midazolam equivalent) effect and recommended timing of EEG and EPs assessments [9, 30, 31, 46]
From: Prognostication after cardiac arrest: how EEG and evoked potentials may improve the challenge
Light-to-moderate sedation effect on EEG and EPs | Recommended timing of EEG and EPs assessment | |
|---|---|---|
EEG | Decrease frequency: slow background Decrease amplitude: low voltage Fast rhythms (mainly with benzodiazepines) | Performed at 72 h after CA Could be performed earlier, at 24 h after CA (if possible, without sedation) Use cEEG monitoring if available in ICU |
SSEP | N20: poorly affected by sedation Decrease SSEP N20–P25 amplitudes | Performed at 72 h after CA Could be performed under sedation if needed (do not use amplitudes results) |
BAEP | BAEP: no influence of sedation BAEP latencies: increased by sedation | Performed at 72 h after CA Could be performed under sedation if needed |
MMN | Risk of false negative if performed under sedation Need sedative drugs elimination | Performed at 72 h after CA Performed 48 h after sedation weaning |
P300 | Risk of false negative if performed under sedation Need sedative drugs elimination | Performed at 72 h after CA Performed 48 h after sedation weaning |