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Table 3 Multivariable analysis of factors associated with favorable functional outcome (mRS 0–3) at one year

From: Cerebrovascular complications and outcomes of critically ill adult patients with infective endocarditis

Variable

Univariate OR [95% CI]

Univariate p

Multivariate OR [95% CI]

Multivariate p

A. All patients (n = 154)

 CT-defined moderate-to-severe ischemic stroke

0.7 [0.3–1.5]

0.34

0.37 [0.14–0.95]

0.038

 Age

0.9 [0.9–1.0]

 < 0.001

0.94 [0.91–0.97]

 < 0.001

 GCS score

1.2 [1.1–1.4]

 < 0.001

1.23 [1.08–1.42]

0.003

 Charlson index ≥ 2

0.6 [0.3–1.1]

0.085

0.54 [0.25–1.18]

0.12

 Non-neurological SOFA ≥ 5

0.5 [0.2–0.9]

0.021

 Mitral valve involvement

0.5 [0.3–1.0]

0.05

0.58 [0.28–1.20]

0.14

B. Operated patients (n = 107)

 CT-defined moderate-to-severe ischemic stroke

0.4 [0.2–1.1]

0.09

0.30 [0.01–0.93]

0.037

 Age

0.9 [0.9–1.0]

0.009

0.96 [0.93–0.99]

0.018

 GCS score

1.2 [1.1–1.4]

0.007

1.24 [1.05–1.47]

0.012

 Charlson index ≥ 2

0.4 [0.2–1.0]

0.05

0.36 [0.14–0.90]

0.03

 Non-neurological SOFA ≥ 5

0.5 [0.3–1.2]

0.13

 Mitral valve involvement

0.6 [0.3–1.3]

0.2

  1. A separate regression analysis was performed for each baseline brain CT category. Minor ischemic stroke, cerebral hemorrhage and normal CT were not significantly associated with 1-year favorable outcome neither in the principal analysis, nor in the operated population. Mitral valve involvement, non-neurological SOFA ≥ 5 and charlson comorbidity index (whole population only) were not retained for the final model during the backward selection procedure (p > 0.2). Variables significantly associated with outcome in multivariable analysis (p < 0.05) are displayed in bold
  2. CT computed tomography, GCS Glasgow Coma Scale, SOFA Sequential Organ Failure Assessment