Table 3 Treatment outcomes of ICU patients with nosocomial pneumonia treated with and without nebulized colistin in substitutive strategya
| Â | Original cohort | p value | PS-matched cohort | p value | ||
|---|---|---|---|---|---|---|
With substitutive nebulized colistin | Without substitutive nebulized colistin | With substitutive nebulized colistin | Without substitutive nebulized colistin | |||
Case number | 343 | 214 | Â | 115 | 115 | Â |
Clinical failure | ||||||
 Day 7 | 95 (27.7%) | 102 (47.7%) |  < 0.001 | 26 (22.6%) | 49 (42.6%) | 0.001 |
 Day 14 | 103 (30.0%) | 104 (48.6%) |  < 0.001 | 31 (27.0%) | 49 (42.6%) | 0.013 |
 Day 28 | 102 (29.7%) | 104 (48.6%) |  < 0.001 | 32 (27.8%) | 48 (41.7%) | 0.027 |
All-cause mortality | ||||||
 Day 14 | 48 (14.0%) | 56 (26.2%) |  < 0.001 | 12 (10.4%) | 21 (18.3%) | 0.090 |
 Day 28 | 78 (22.7%) | 67 (31.3%) | 0.025 | 19 (16.5%) | 26 (22.6%) | 0.245 |
 Hospital mortality | 136 (39.7%) | 97 (45.3%) | 0.186 | 42 (36.5%) | 42 (36.5%) | 1.000 |
28-day ventilator weaningb | 164 (55.8%) | 96 (48.5%) | 0.112 | 55 (55.6%) | 59 (55.7%) | 0.988 |
28-day new dialysis | 20 (5.8%) | 12 (5.6%) | 0.912 | 8 (7.0%) | 9 (7.8%) | 0.801 |
ICU stays (Median, IQR) | 32.1 (24.2) | 26.9 (22.1) | 0.011 | 25 (15–47) | 23 (14–40) | 0.245 |
Hospital stays (Median, IQR) | 63.5 (45.1) | 51.0 (36.2) | 0.001 | 53 (34–90) | 48 (31–71) | 0.332 |