Skip to main content
Annals of Intensive Care

Table 4 Univariate and multivariate analyses of clinical factors associated with day 14 clinical failure in ICU patients with nosocomial pneumonia caused by CR-GNB

From: Role of nebulized colistin as a substitutive strategy against nosocomial pneumonia caused by CR-GNB in intensive care units: a retrospective cohort study

 

Original cohorta

PS-matched cohorta

Univariate analysis

Multivariate analysis

Univariate analysis

Multivariate analysis

OR (95% CI)

p value

aOR (95% CI)

p value

OR (95% CI)

p value

aOR (95% CI)

p value

Age

1.00 (0.99–1.01)

0.554

  

0.98 (0.97–1)

0.041

0.99 (0.97–1.01)

0.175

Male

1.15 (0.79–1.67)

0.479

  

0.97 (0.54–1.75)

0.916

  

BMI

0.99 (0.96–1.03)

0.674

  

0.96 (0.91–1.02)

0.211

  

CRAB

1.12 (0.72–1.76)

0.607

  

0.93 (0.48–1.81)

0.823

  

Medical ICU

1.53 (1.08–2.17)

0.017

1.58 (1.06–2.35)

0.024

0.9 (0.52–1.57)

0.711

  

Smoking

1.12 (0.73–1.71)

0.615

  

0.99 (0.56–1.76)

0.970

  

Malignancies

0.85 (0.52–1.39)

0.519

  

1.07 (0.51–2.25)

0.855

  

Renal insufficiency

0.93 (0.60–1.43)

0.727

  

1.72 (0.87–3.4)

0.118

  

Chronic lung diseases

0.70 (0.48–1.01)

0.054

1.07 (0.66–1.72)

0.790

1.09 (0.55–2.16)

0.807

  

Diabetes

1.05 (1.02–1.08)

 < 0.001

0.76 (0.51–1.14)

0.185

0.66 (0.36–1.19)

0.162

  

APACHE II score

1.17 (1.11–1.23)

 < 0.001

1.03 (1.00–1.06)

0.056

1.01 (0.96–1.05)

0.769

  

SOFA scorec

2.51 (1.66–3.79)

 < 0.001

1.12 (1.05–1.19)

0.001

1.19 (1.09–1.29)

0.000

1.16 (1.05–1.28)

0.004

PF ratio ≤ 200c

2.30 (1.40–3.78)

0.001

1.83 (1.13–2.94)

0.013

2.27 (1.2–4.3)

0.012

1.57 (0.74–3.33)

0.242

Septic shock c

1.19 (0.73–1.96)

0.482

  

1.78 (0.69–4.57)

0.234

  

Albumin ≤ 3 mg/dL

1.48 (1.05–2.09)

0.025

1.4 (0.95–2.05)

0.088

1.39 (0.81–2.4)

0.234

  

Inappropriate empiric therapy

1.54 (1.01–2.36)

0.047

1.64 (1.04–2.59)

0.033

1.77 (0.90–3.50)

0.098

2.01 (0.98–4.14)

0.058

Substitutive nebulized colistind

0.45 (0.32–0.65)

 < 0.001

0.45 (0.30–0.67)

 < 0.001

0.5 (0.29–0.87)

0.013

0.48 (0.27–0.87)

0.015

  1. APACHE II, Acute Physiology and Chronic Health Evaluation II; CRAB, carbapenem-resistant Acinetobacter baumannii; ICU, intensive care unit; PF ratio, PaO2/FiO2 ratio; SOFA, Sequential Organ Failure Assessment
  2. aAdjusted odds ratio (aOR) and 95%CI were derived from logistic regression analysis
  3. bSOFA score on pneumonia index date
  4. cPresence of organ dysfunction on the pneumonia index date
  5. dAs substitutive strategy
Back to article page