Isoflurane vs. propofol for sedation in invasively ventilated patients with acute hypoxemic respiratory failure: an a priori hypothesis substudy of a randomized controlled trial

Annals of Intensive Care

Table 1 Patient demographics

Variable	Category	Isoflurane (n = 72)	Propofol (n = 90)	Total (n = 162)	p (isoflurane vs. propofol)
Age (yrs)	Mean (± SD)	66 (± 11)	65 (± 12)	65.5 (± 12)	0.585
Age (yrs)	Min/Max	32/87	33/92	32/92
Sex	F	19 (26.4%)	29 (32.2%)	48 (29.6%)	n.a
Sex	M	53 (73.6%)	61 (67.8%)	114 (70.4%)
Height (cm)	Mean (± SD)	174 (± 9)	173 (± 9)	174 (± 9)	1.000
Height (cm)	Min/Max	148/200	155/198	148/200
Weight (kg)	Mean (± SD)	89 (± 22)	88 (± 24)	88 (± 23)	0.785
Weight (kg)	Min/Max	50/148	52/170	50/170
BMI (kg/m²)	Mean (± SD)	29.2 (± 6.9)	29.3 (± 8.0)	29.3 (± 7.5)	0.933
BMI (kg/m²)	Min/max	15.4/55.7	16.9/63.2	15.4/63.2
SAPS II	Mean	47 ± 14 (n = 58)	45 ± 18 (n = 71)	46 ± 16 (n = 129)	0.490
SAPS II	Min/max	14/86	13/88	13/88
SOFA	Mean (± SD)	10.6 (± 3.4)	10.3 (± 3.3)	10.4 (± 3.3)	0.571
SOFA	Min/max	2/18	2/16	2/18
PaO₂/FiO₂ (mmHg)	Mean (± SD)	199 (± 58)	202 (± 62)	200.5 (± 60)	0.753
PaO₂/FiO₂ (mmHg)	Min/max	84/298	70/298	70/298
Main Reason for ICU Admission	Medical Neurosurgical	35 (48.6%) 1 (1.4%)	43 (47.8%) 0	78 (48.1%) 1 (0.6%)	n.a
Main Reason for ICU Admission	Surgical Trauma	33 (45.8%) 3 (4.2%)	41 (45.6%) 6 (6.7%)	74 (45.7%) 9 (5.6%)

BMI body mass index, SAPS II Simplified Acute Physiology Score, SOFA Sequential Organ Failure Assessment, N.a. not available