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Fig. 2 | Annals of Intensive Care

Fig. 2

From: Auto-antibodies against type I IFNs in > 10% of critically ill COVID-19 patients: a prospective multicentre study

Fig. 2

Distribution of auto-antibodies (auto-Abs) to specific sets of type I interferons (IFNs) according to 28-day mortality. a Proportion of specific sets of auto-Abs (several patients have more than one auto-Abs resulting in total number being greater than 96; b proportion of combinations of auto-Abs to specific sets of type I IFNs (total numbers add-up to 96); α2: auto-Abs anti-IFN-α2; ω: auto-Abs anti-IFN-ω; β: auto-Abs anti-IFN-β; *including 6 patients who also had anti-IFN-α2 (10 ng/mL) auto-Abs; #including 2 patients who also had anti-IFN-ω (10 ng/mL) auto-Abs; $including 6 patients who had anti-IFN-α2 (100 pg/mL) and anti-IFN-ω (100 pg/mL), 4 patients with anti-IFN-α2 (100 pg/mL + 10 ng/mL) and anti-IFN-ω (10 ng/mL), 35 patients with anti-IFN-α2 (100 pg/mL + 10 ng/mL) and anti-IFN-ω (100 pg/mL + 10 ng/mL), 6 patients with IFN-α2 (100 pg/mL + 10 ng/mL) and anti-IFN-ω (100 pg/mL) and 1 patient with IFN-α2 (10 ng/mL) + anti-IFN-ω (100 pg/mL + 10 pg/mL) auto-Abs; c distribution of patients with simple, double or triple positive auto-Abs; P value comes from the Fisher exact test. Patients who were alive at 28-day are shown in light blue and patients who were dead at 28-day are shown in dark blue (b, c); NS: p-value > 0.05

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