Total | Negative anti-IFN auto-Abs | Positive anti-IFN auto-Abs | p-valuea | |
---|---|---|---|---|
N = 925 | N = 829 | N = 96 | ||
Comorbidities | ||||
Ageb | 62 (53;69.7) | 62.0 (53;69.5) | 63.8 (53.9;70.5) | 0.668 |
Gender | 0.083 | |||
Maleb | 652 (70.5) | 577 (69.6) | 75 (78.1) | |
Female | 273 (29.5) | 252 (30.4) | 21 (21.9) | |
Obesityb (N = 861) | 370 (43.0) | 335 (43.4) | 35 (39.3) | 0.463 |
Diabetesb | 301 (32.5) | 278 (33.5) | 23 (24.0) | 0.058 |
Congestive heart failurec | 94 (10.2) | 85 (10.3) | 9 (9.4) | 0.787 |
Vasculopathy | 101 (10.9) | 87 (10.5) | 14 (14.6) | 0.224 |
Hypertensionb | 474 (51.2) | 429 (51.8) | 45 (46.9) | 0.366 |
COPD | 62 (6.7) | 60 (7.2) | 2 (2.1) | 0.053 |
Chronic kidney diseased | 106 (11.5) | 97 (11.7) | 9 (9.4) | 0.498 |
ESRD requiring dialysis | 42 (4.5) | 37 (4.5) | 5 (5.2) | 0.794 |
Cirrhosis | 13 (1.4) | 11 (1.3) | 2 (2.1) | 0.636 |
Current smoking | 124 (13.4) | 107 (12.9) | 17 (17.7) | 0.191 |
Immunosuppressionb | 100 (10.8) | 95 (11.5) | 5 (5.2) | 0.080 |
Solid cancer | 31 (3.4) | 28 (3.4) | 3 (3.1) | 1.000 |
HIV infection | 15 (1.6) | 15 (1.8) | 0 (0) | 0.388 |
Haematological malignancy | 17 (1.8) | 17 (2.1) | 0 (0) | 0.243 |
Clinical Frailty Scale | 3 (2;4) | 3 (2;4) | 3 (2;3) | 0.173 |
Characteristics at ICU admission | ||||
SAPS II (N = 914) | 34 (26;44) | 34 (26;44) | 34.5 (29;44) | 0.433 |
SOFA scoreb (N = 917) | 4 (2;6) | 4 (2;6) | 4 (2;7) | 0.343 |
WHO CPS(N = 920) | 6 (6;8) | 6 (6;8) | 7 (6;8) | 0.188 |
Time from first symptoms to ICU admission (days) | 9 [6–12] | 9 [6–12] | 8 [6–12] | 0.531 |
Admission period | 0.004 | |||
First wavee | 140 (15.1) | 115 (13.9) | 25 (26) | |
Second wavef | 785 (84.9) | 714 (86.1) | 71 (73.9) | |
Temperature (N = 857) | 37 (36.9;38) | 37 (36.9;38) | 37.4 (36.7;38.1) | 0.299 |
FiO2 (%) (N = 908) | 90 (60;100) | 90 (60;100) | 100 (70;100) | 0.010 |
PaO2 (mmHg) (N = 906) | 73 (61;91) | 72 (61;91) | 76 (63.5;89) | 0.259 |
PaO2/FiO2 ratio (N = 903) | 0.96 (0.7;1.4) | 0.97 (0.70;1.4) | 0.9 (0.7;1.3) | 0.427 |
PaCO2 (mmHg) (N = 895) | 37 (32;43) | 37 (32;43) | 38 (34;45) | 0.118 |
Arterial lactate (mmol/L) (N = 889) | 1.4 (1.2;1.9) | 1.4 (1.2;1.9) | 1.5 (1.1;2.1) | 0.898 |
White blood cell counts (G/L) (N = 920) | 8.80 (6.1;12.8) | 8.5 (5.9;12.3) | 11.41 (8.3;14.7) | < 0.0001 |
Neutrophil counts (G/L) (N = 736) | 7.8 (5.2;11.3) | 7.44 (5;11) | 10.2 (6.4;13.8) | 0.0002 |
Lymphocyte counts (G/L) (N=733) | 0.7 (0.5;1) | 0.7 (0.5;1) | 0.7 (0.5;1.1) | 0.976 |
Monocyte counts (G/L) (N = 732) | 0.4 (0.2;0.6) | 0.40(0.2;0.6) | 0.5 (0.3;0.8) | 0.008 |
Plasma creatinine level (µmol/L) (N = 922) | 76 (60;108) | 76 (59;109) | 81 (64;103.5) | 0.297 |
D-dimers (ng/mL) (N = 510) | 1344.5 (846;2614) | 1343 (837;2511) | 1380 (937;3488) | 0.258 |
Corticosteroid | 44 (4.8) | 42 (5.1) | 2 (2.1) | 0.307 |
Antibiotic treatmentb | 635 (68.6) | 564 (68.0) | 71 (74.0) | 0.236 |
Oxygen therapy | 51 (5.5) | 46 (5.6) | 5 (5.2) | 0.890 |
High flow oxygen therapy | 525 (56.8) | 474 (57.2) | 51 (53.1) | 0.448 |
Invasive mechanical ventilation | 441 (47.7) | 388 (46.8) | 53 (55.2) | 0.119 |
ARDS | 862 (93.2) | 772 (93.1) | 90 (93.8) | 0.818 |
Shock | 178 (19.2) | 156 (18.8) | 22 (22.9) | 0.335 |
Renal replacement therapy | 98 (10.6) | 88 (10.6) | 10 (10.4) | 0.952 |
Neuromuscular blockade | 404 (43.7) | 359 (43.4) | 45 (46.9) | 0.511 |