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Annals of Intensive Care

Table 2 Association of hypotension exposure with ICU mortality for different thresholds

From: Association of systolic, diastolic, mean, and pulse pressure with morbidity and mortality in septic ICU patients: a nationwide observational study

 

N

Death (%)

Adjusted OR

95% CI

P value

Lowest MAP ≥ 75 mmHg

7926

38 (0.5%)

Reference

  

Lowest MAP < 75 mmHg

69,402

2735 (3.9%)

4.24

3.06 to 5.87

 < 0.001

Lowest MAP < 65 mmHg

51,230

2582 (5.0%)

5.49

3.96 to 7.60

 < 0.001

Lowest MAP < 55 mmHg

17,283

1682 (9.7%)

10.95

7.86 to 15.26

 < 0.001

Lowest MAP < 45 mmHg

1611

473 (29.4%)

48.70

33.02 to 71.84

 < 0.001

Lowest SBP ≥ 110 mmHg

9977

36 (0.4%)

Reference

  

Lowest SBP < 110 mmHg

67,351

2737 (4.1%)

6.02

4.32 to 8.40

 < 0.001

Lowest SBP < 100 mmHg

55,672

2668 (4.8%)

7.07

5.07 to 9.87

 < 0.001

Lowest SBP < 90 mmHg

33,436

2428 (7.3%)

11.03

7.90 to 15.41

 < 0.001

Lowest SBP < 80 mmHg

9752

1516 (15.5%)

25.38

18.06 to 35.67

 < 0.001

Lowest DBP ≥ 60 mmHg

7954

44 (0.6%)

Reference

  

Lowest DBP < 60 mmHg

69,371

2729 (3.9%)

3.82

2.82 to 5.17

 < 0.001

Lowest DBP < 50 mmHg

46,073

2407 (5.2%)

5.29

3.90 to 7.19

 < 0.001

Lowest DBP < 40 mmHg

14,005

1295 (9.2%)

10.78

7.84 to 14.82

 < 0.001

Lowest DBP < 30 mmHg

1491

303 (20.3%)

31.46

20.78 to 47.63

 < 0.001

40 ≤ Lowest PP < 50 mmHg

14,805

238 (1.6%)

Reference

  

Lowest PP ≥ 50 mmHg

8419

80 (1%)

0.70

0.53 to 0.92

0.011

Lowest PP < 40 mmHg

54,104

2455 (4.5%)

2.37

2.06 to 2.73

 < 0.001

Lowest PP < 30 mmHg

26,917

1787 (6.6%)

3.35

2.90 to 3.87

 < 0.001

Lowest PP < 20 mmHg

6278

687 (10.9%)

4.99

4.21 to 5.90

 < 0.001

  1. The entire population was categorized into subgroups using several thresholds for each blood pressure component. MAP ≥ 75 mmHg, SBP ≥ 110 mmHg, DBP ≥ 60 mmHg, and 40 ≤ PP < 50 mmHg were selected as reference groups, respectively. Multivariable logistic regression was conducted to quantitatively evaluate the risk of ICU mortality for different thresholds. Age, BMI, APACHE IVa score, ethnicity, admission type, admission year, hospital bed size, hemoglobin, albumin, WBC, BUN, and lactate were selected as covariates. The effect of hypotension exposure on ICU mortality in the lowest pressure category was smaller in PP compared to MAP, SBP, and DBP
  2. APACHE Acute Physiology and Chronic Health Evaluation, BMI body mass index, BUN blood urea nitrogen, CI confidence interval, DBP diastolic blood pressure, ICU intensive care unit, MAP mean arterial pressure, OR odds ratio, PP pulse pressure, SBP systolic blood pressure
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