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Table 1 Clinical characteristics at hospital admission of not vaccinated and fully vaccinated patients.

From: Differences in clinical characteristics and quantitative lung CT features between vaccinated and not vaccinated hospitalized COVID-19 patients in Italy

 

Total

n = 684

Not vaccinated

n = 580 (84.8%)

Fully vaccinated

n = 104 (15.2%)

p

Demographic characteristics

Age, years

69 [55–80]

67 [53–79]

78 [69–84]

 < 0.001

Male sex, n (%)

398 (58.2)

334 (57.6)

64 (61.5)

0.452

Caucasian, n (%)

600 (87.7)

502 (86.5)

98 (94.2)

0.566

Latin/hispanic, n (%)

24 (3.5)

22 (3.8)

2 (1.9)

Other, n (%)

60 (8.7)

56 (9.7)

4 (3.8)

Underlying comorbidities

Hypertension, n (%)

300 (43.9)

245 (42.2)

55 (52.9)

0.044

Stroke, n (%)

33 (4.8)

26 (4.5)

7 (6.7)

0.325

AMI, n (%)

70 (10.2)

48 (8.3)

22 (21.1)

 < 0.001

Diabetes, n (%)

133 (19.4)

104 (17.9)

29 (27.9)

0.018

Cardiovascular diseases n (%)

135 (19.7)

96 (16.5)

39 (37.5)

 < 0.001

COPD, n (%)

64 (9.4)

41 (7.1)

23 (22.1)

 < 0.001

History of cancer, n (%)

58 (8.5)

38 (6.6)

20 (19.2)

 < 0.001

CKD, n (%)

48 (7)

35 (6)

13 (12.5)

0.017

Chronic liver disease, n (%)

15 (2.2)

9 (1.6)

6 (5.8)

0.007

Age-adjusted Charlson score

3 [1–4]

3 [1–4]

4 [3–6]

 < 0.001

Laboratory data

Haemoglobin, g/dL

13.5 [12.0–14.7]

13.7 [12.2–14.9]

12.9 [11.3–14.1]

0.005

CRP, mg/L

52.9 (29.2–84.2)

52.2 [27.1–82.1]

60.6 [35.9–102.8]

0.018

LDH, U/L

293 [235–380]

297 [246–397]

263 [215–338]

0.002

Leukocytes count, 103/µL

6.21 [4.65–8.72]

6.1 [4.51–8.73]

6.64 [4.65–8.7]

0.382

Platelets,103/µL

186 [144–247]

186 [146–239]

183 [135–260]

0.910

D-Dimer, ng/µL

320 [211–616]

314 [214–606]

383 [196–690]

0.562

GPT, U/L

29 [19–49]

30 [20–51]

24 [17–43]

0.086

GOT, U/L

44 [19–49]

44 [34–63]

39 [29–60]

0.086

Creatinine, mg/dL

0.9 [0.7–1.2]

0.8 [0.7–1.1]

1 [0.8–1.5]

 < 0.001

Procalcitonin, µg/L

0.17 [0.07–0.63]

0.17 [0.07–0.73]

0.22 [0.18–0.26]

0.636

Ferritin, ng/mL

339 [186–692]

357 [182–708]

314 [305–442]

0.960

Pharmacological treatments

Remdesivir, n (%)

174 (25.4)

169 (29.1)

5 (4.8)

 < 0.001

Heparin profilaxis, n (%)

561 (82)

479 (82.6)

82 (78.8)

0.360

Corticosteroid treatment, n (%)

579 (84.6)

495 (85.3)

84 (80.8)

0.233

Biological immunomodulator, n (%)

49 (7.2)

42 (7.2)

2 (1.9)

0.024

Monoclonal antibodies, n (%)

50 (7.3)

22 (3.8)

28 (26.9)

 < 0.001

  1. Continuous variables are expressed as median [IQR] and compared with Mann–Whitney U test, while categorical data are expressed as n (%) and compared with Chi-square test
  2. COPD  chronic obstructive pulmonary disease, AMI acute myocardial infarction, CKD  chronic kidney disease, CRP  C-reactive protein, LDH  lactate dehydrogenase, GOT  glutamic–oxalacetic transaminase, GPT  glutamate–pyruvate transaminase. History of cancer was defined as a cancer diagnosis in the last 5 years