Table 3 Factors associated with adequate beta-lactam concentration (> 4 times the MIC threshold)
Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|
Inadequate (N = 22) | Adequate (N = 90) | p value | OR [CI 95%] | p value | |
Sex (female), N (%) | 7 (31.8) | 29 (32.2) | 0.97 | ||
Age (year), mean (SD) | 67.0 (10.0) | 64.3 (13.7) | 0.57 | ||
Weight (kg), mean (SD) | 84.5 (12.8) | 86.1 (20.9) | 0.67 | ||
Delay between ICU admission and randomization, median [IQ] | 1.5 [1–4.75] | 1 [1, 2] | |||
Chronic kidney disease, N (%) | 0 (0) | 7 (7.8) | 0.34 | ||
Delayed strategy group (AKIKI randomization), N (%) | 11 (50) | 48 (53.3%) | 0.78 | 1.18 [0.40–3.45] | 0.767 |
SAPS III, mean (SD) | 70.0 (8.4)a | 70.7 (14.4)b | 0.97 | ||
Administration of aminoglycosides | 4/14 (28.6%) | 33/56 (58.9%) | 0.04 | 2.24 [0.58–8.72] | 0.23 |
Administration of vancomycin | 1/14 (7.1%) | 11/56 (19.6%) | 0.43 | ||
Septic shock, N (%) | 10 (45.5) | 73 (81.1) | 0.0006 | 3.95 [1.14–13.64] | 0.029 |
Mean arterial pressure (mmHg), mean (SD) | 70 (7) | 77 (16) | 0.0181 | 1.05 [1.01–1.10] | 0.013 |
Cardiac rate (beats per minute), mean (SD) | 99 (24) | 111 (28) | 0.053 | ||
Serum creatinine (µM), mean (SD) | 231.3 (100.8) | 289.6 (112.5) | 0.024 | 1.01 [1.00–1.01] | 0.062 |
Serum urea (mM), mean (SD) | 17.6 (8.2) | 18.5 (8.0) | 0.82 | ||
Serum bicarbonate (mM), mean (SD) | 21.3 (5.6) | 19.0 (4.4)a | 0.045 | 0.97 [0.86–1.09] | 0.585 |
Arterial blood lactate (mM), mean (SD) | 2.5 (1.8)c | 2.7 (2.4)d | 0.98 | ||