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Table 2 Patients’ microbiological presentation, bacterial species, and antibiotic susceptibility test

From: Efficacy of carbapenem vs non carbapenem β-lactam therapy as empiric antimicrobial therapy in patients with extended-spectrum β-lactamase-producing Enterobacterales urinary septic shock: a propensity-weighted multicenter cohort study

 

Total (n = 156)

Carbapenem therapy (n = 69)

Non-carbapenem therapy (n = 87)

p-value

Microbiological presentation

 Blood cultures performed

145 (93)

63 (91)

82 (94)

0.69

 Concomitant bloodstream infection

109 (75)

52 (82)

57 (69)

0.07

 Coinfection

6 (4)

3 (4)

3 (3)

1

 ESBL fecal carriage

50 (32)

21 (30)

29 (33)

0.31

Bacterial species

 Escherichia coli

79 (51)

33 (48)

46 (53)

0.73

 Klebsiella pneumoniae

46 (29)

22 (32)

24 (27)

 Enterobacter cloacae

15 (10)

8 (12)

7 (8)

 Klebsiella oxytoca,

4 (2)

2 (3)

2 (2)

 Proteus mirabilis

4 (2)

2 (3)

2 (2)

 Citrobacter koseri

3 (2)

2 (3)

1 (1)

 Citrobacter freundii

3 (2)

0 (0)

3 (3)

 Morganella morganii

2 (1)

0 (0)

2 (2)

Antibiotic susceptibility test

 Susceptibility to piperacillin–tazobactam

90 (60)

33 (48)

57 (65)

0.06

 Susceptibility to aminoglycoside

142 (91)

62 (90)

80 (92)

0.91

 Susceptibility to piperacillin–tazobactam and/or aminoglycoside

148 (95)

65 (94)

83 (95)

1

 Susceptibility to cefoxitin

91 (58)

37 (54)

54 (62)

0.06

 Susceptibility to ertapenem, n (%)

148 (95)

64 (93)

84 (96)

0.45

 Susceptibility to fluoroquinolone, n (%)

20 (13)

7 (10)

13 (15)

0.47

 Susceptibility to cotrimoxazole/trimethoprim, n (%)

46 (29)

23 (33)

23 (26)

0.38

  1. Results are presented as proportion (percentage) for categorical variables and median [interquartile range] for continuous variables
  2. p-values are for comparison between carbapenem group and non carbapenem group. Threshold for statistical significance: p = 0.05