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Table 1 Characteristics of the patients at baselinea

From: Long-term outcomes after severe acute kidney injury in critically ill patients: the SALTO study

 

AKIKI trial

Surviving patients 60 days after randomization

Surviving patients with Scr available beyond D90 after randomization

No of patients

N = 619

All N = 316

Early RRT strategy N = 161

Delayed RRT strategy N = 155

N = 175

Age—yr

66 ± 13.8

62.3 ± 14.7

60.8 ± 14.7

64 ± 14.7

62 ± 13

Sex—no. (%)

 

Female

212(34)

110 (35)

55 (34)

55 (35)

60(34)

Male

407(66)

206 (65)

106(66)

100 (65)

115 (66)

Serum creatinine before ICU admission—mg/dlb

0.96 ± 0.28

0.95 ± 0.27

0.94 ± 0.25

0.96 ± 0.29

0.92 ± 0.23

Coexisting conditions—no. (%)

 

Chronic kidney diseasec

118 (19)

50 (16)

23(14)

27(17)

7(4)

Hypertension

328 (53)

153(48)

71(44)

82(53)

70 (40)

Diabetes mellitus

163 (26)

77 (24)

42(26)

35(23)

35(20)

Congestive heart failure

56 (9)

17 (5)

8 (5)

9(6)

3(2)

SAPS III at Enrollmentd

73.1 ± 14.3

70.4 ± 14.8

70.8 ± 15.12

70 ± 14.05

66 ± 11

SOFA score at enrollmente

10.9 ± 3.2

10.3 ± 3

10.5 ± 3.11

10.16 ± 2.85

9.8 ± 2.6

Exposure to at least one nephrotoxic agent within two days before ICU—no./total no. (%)g

All

389 (63)

178 (56)

93 (58)

85 (55)

92(53)

Intravenous contrast

137 (22)

70 (22)

34/93 (37)

36/85 (42)

35/92 (38)

Aminoglycoside

212(34)

95 (30)

52/93 (56)

43/85 (51)

30/92 (33)

Vancomycin

55 (9)

27 (8)

12/93 (13)

15/85 (18)

5/92 (5)

Septic shockg

413 (67)

167 (53)

80 (50)

87 (56)

43/92 (47)

  1. aPlus–minus values are means ± SD. To convert values for creatinine to micromoles per liter, multiply by 88.4
  2. bThe serum creatinine concentration before ICU admission was either determined with the use of values measured in the 12 months preceding the ICU stay or was estimated
  3. cKidney function was reassessed with Cockcroft formula using available serum creatinine at baseline
  4. dThe Simplified Acute Physiology Score (SAPS) III ranges from 0 to 146, with higher scores indicating more severe disease and a higher risk of death
  5. eThe Sepsis-related Organ Failure Assessment (SOFA) score ranges from 0 to 24, with higher scores indicating more severe organ failure
  6. fSome patients were exposed to more than one nephrotoxic agent
  7. gSeptic shock was defined as sepsis induced hypotension despite fluid resuscitation of at least 30 ml per kilogram of body weight of intravenous fluid administered within the period spanning the 4 h before and 4 h after initiation of vasopressor therapy