Electroencephalography for prognostication of outcome in adults with severe herpes simplex encephalitis

Table 2 Association of _stdEEG reactivity with poor functional outcome, multivariable analyses

	Model including EEG variables		Model including clinical and EEG variables
	Adjusted odds ratio*	95% CI	Adjusted odds ratio**	95% CI
Whole cohort (n = 214)
Present reactivity	1	–	1	–
Reactivity not tested	1.11	0.53–2.30	0.73	0.45–1.20
Absent reactivity	2.80	1.19–6.58	2.03	1.18–3.49
Patients under mechanical ventilation (n = 138)
Present reactivity	1	–	1	–
Reactivity not tested	1.92	0.73–5.07	1.12	0.57–2.20
Absent reactivity	4.99	1.60–15.59	2.62	1.25–5.50

^*Odds ratios presented in the model including EEG variables are adjusted for maximal background frequency
^**Odds ratios presented in the model including clinical and EEG variables are adjusted for maximal background frequency, age, Glasgow coma score < 8, temperature ≥ 38.3 °C, time between ICU admission and _stdEEG > 1 day, and the presence of sedation at the time of EEG recording. The AUC [95%CI] of the final model was 0.764 [95% CI, 0.759 to 0.769]