Table 2 In-ICU complications and management according to ICU survival status
From: Critically ill severe hypothyroidism: a retrospective multicenter cohort study
Characteristic | Total | ICU survivors | ICU nonsurvivors | p |
|---|---|---|---|---|
(n = 82) | (n = 61) | (n = 21) | ||
In-ICU complications | ||||
VAP | 26 (32) | 15 (25) | 11 (52) | 0.018 |
Cardiogenic shock | 15 (18) | 8 (13) | 7 (33) | 0.052 |
Acute coronary syndrome | 1 (1) | 0 (0) | 1 (5) | 0.256 |
Cardiac arrest | 2 (2) | 1 (2) | 1 (5) | 0.449 |
Ventricular fibrillation or tachycardia | 2 (2) | 2 (3) | 0 (0) | 1.000 |
Supraventricular tachycardia | 3 (4) | 2 (3) | 1 (5) | 1.000 |
Ileus | 8 (10) | 6 (10) | 2 (9) | 1.000 |
Therapeutic management | ||||
Organ support | ||||
Any vasopressors | 30 (37) | 18 (29) | 12 (57) | 0.035 |
Dobutamine | 14 (17) | 7 (11) | 7 (33) | 0.039 |
Isoprenaline | 7 (8) | 6 (10) | 1 (5) | 0.671 |
Temporary transvenous ventricular pacing | 2 (2) | 1 (2) | 1 (5) | 0.449 |
Non-invasive mechanical ventilation | 24 (29) | 18 (29) | 6 (29) | 1.000 |
Invasive mechanical ventilation | 54 (66) | 36 (59) | 18 (86) | 0.033 |
Duration (days) | 6.5 (4.0–12.0) | 5.0 (3.0–8.0) | 11.0 (5.0–27.0) | 0.034 |
RRT | 17 (21) | 6 (10) | 11 (52) | < 0.001 |
Pericardial drainage | 2 (2) | 2 (3) | 0 (0) | 1.000 |
Specific hypothyroidism treatment | ||||
Loading dose (binary) | 35 (43) | 25 (41) | 10 (48) | 0.618 |
Loading dose (µg) | 300 (175–400) | 300 (200–400) | 250 (125–375) | 0.52 |
Time between hospital admission and levothyroxine start (days) | 1.0 (0.0–4.0) | 1.0 (0.0–4.0) | 1.0 (1.0–4.0) | 0.526 |
Time between ICU admission and levothyroxine start (days) | 0.0 (0.0–2.0) | 0.0 (0.0–2.0) | 0.0 (− 1.0 to 2.0) | 0.919 |
Starting dose of Levothyroxine (µg) | 100 (50–125) | 100 (50–125) | 100 (62–125) | 0.594 |
Levothyroxine administration | 1.000 | |||
Intravenous | 39 (48) | 29 (48) | 10 (48) | |
Oral | 40 (49) | 30 (49) | 10 (48) | |
Corticosteroids | 52 (63) | 37 (61) | 15 (71) | 0.440 |