Outcome | 12 mg of dexamethasone (n = 180) | 6 mg of dexamethasone (n = 177) | Absolute differences (%) | 95% CI (%) | p-valuea |
---|---|---|---|---|---|
Death or thromboembolism | 53 (29) | 53 (30) | − 0.50 | − 10 to 9.5 | 1.00 |
Death | 40 (22) | 40 (23) | − 0.38 | − 9.4 to 8.7 | 1.00 |
Thromboembolism | 18 (10) | 18 (10) | − 0.17 | − 6.6 to 6.2 | 1.00 |
Pulmonary embolism | 14 (7.8) | 17 (9.6) | − 1.8 | − 8.2 to 4.6 | 0.67 |
Deep vein thrombosis | 0 (0) | 0 (0) | 0.00 | ||
Myocardial infarction | 2 (1.1) | 0 (0) | 1.1 | − 1.0 to 3.2 | 0.49 |
Stroke | 1 (0.6) | 0 (0) | 0.56 | − 1.1 to 2.2 | 1.00 |
Other thrombotic event | 3 (1.7) | 3 (1.7) | − 0.03 | − 2.7 to 2.7 | 1.00 |
Type of bleeding | |||||
Major bleeding | 10 (5.6) | 10 (5.6) | − 0.09 | − 5.0 to 4.8 | 1.00 |
Any bleeding | 35 (19) | 41 (23) | − 3.7 | − 13 to 5.3 | 0.47 |
Site of bleeding | |||||
Upper airway bleeding | 13 (7.2) | 16 (9.0) | − 1.8 | − 8.0 to 4.4 | 0.66 |
Lower airway bleeding | 4 (2.2) | 6 (3.4) | − 1.2 | − 5.2 to 2.8 | 0.73 |
Intrathoracic airway bleeding (hemothorax, mediastinum, pleura), | 0 (0) | 3 (1.7) | − 1.7 | − 4.2 to 0.77 | 0.24 |
Skin (petechiae, ecchymosis, purpura), | 4 (2.2) | 3 (1.7) | 0.53 | − 2.9 to 3.9 | 1.00 |
IV lines: bleeding from catheters, drains, iv lines | 9 (5.0) | 8 (4.5) | 0.48 | − 4.4 to 5.4 | 1.00 |
Muscle: bleeding in muscle or soft tissue, | 5 (2.8) | 4 (2.3) | 0.52 | − 3.2 to 4.3 | 1.00 |
Upper GI bleeding | 9 (5.0) | 9 (5.1) | − 0.08 | − 4.7 to 4.5 | 1.00 |
Lower GI bleeding | 5 (2.8) | 2 (1.1) | 1.6 | − 1.8 to 5.1 | 0.46 |
Intracranial bleeding | 1 (0.6) | 1 (0.6) | − 0.01 | − 1.6 to 1.5 | 1.00 |
Post-surgical bleeding | 5 (2.8) | 4 (2.3) | 0.52 | − 3.2 to 4.3 | 1.00 |
Genitourinary bleeding | 5 (2.8) | 5 (2.8) | − 0.05 | − 3.5 to 3.4 | 1.00 |