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Table 2 Primary and secondary outcomes by dose of dexamethasone

From: Effects of 12 mg vs. 6 mg dexamethasone on thromboembolism and bleeding in patients with critical COVID-19 - a post hoc analysis of the randomized, blinded COVID STEROID 2 trial

Outcome

12 mg of dexamethasone (n = 180)

6 mg of dexamethasone (n = 177)

Absolute differences (%)

95% CI (%)

p-valuea

Death or thromboembolism

53 (29)

53 (30)

− 0.50

− 10 to 9.5

1.00

Death

40 (22)

40 (23)

− 0.38

− 9.4 to 8.7

1.00

Thromboembolism

18 (10)

18 (10)

− 0.17

− 6.6 to 6.2

1.00

Pulmonary embolism

14 (7.8)

17 (9.6)

− 1.8

− 8.2 to 4.6

0.67

Deep vein thrombosis

0 (0)

0 (0)

0.00

  

Myocardial infarction

2 (1.1)

0 (0)

1.1

− 1.0 to 3.2

0.49

Stroke

1 (0.6)

0 (0)

0.56

− 1.1 to 2.2

1.00

Other thrombotic event

3 (1.7)

3 (1.7)

− 0.03

− 2.7 to 2.7

1.00

Type of bleeding

 Major bleeding

10 (5.6)

10 (5.6)

− 0.09

− 5.0 to 4.8

1.00

 Any bleeding

35 (19)

41 (23)

− 3.7

− 13 to 5.3

0.47

Site of bleeding

 Upper airway bleeding

13 (7.2)

16 (9.0)

− 1.8

− 8.0 to 4.4

0.66

 Lower airway bleeding

4 (2.2)

6 (3.4)

− 1.2

− 5.2 to 2.8

0.73

 Intrathoracic airway bleeding (hemothorax, mediastinum, pleura),

0 (0)

3 (1.7)

− 1.7

− 4.2 to 0.77

0.24

 Skin (petechiae, ecchymosis, purpura),

4 (2.2)

3 (1.7)

0.53

− 2.9 to 3.9

1.00

 IV lines: bleeding from catheters, drains, iv lines

9 (5.0)

8 (4.5)

0.48

− 4.4 to 5.4

1.00

 Muscle: bleeding in muscle or soft tissue,

5 (2.8)

4 (2.3)

0.52

− 3.2 to 4.3

1.00

 Upper GI bleeding

9 (5.0)

9 (5.1)

− 0.08

− 4.7 to 4.5

1.00

 Lower GI bleeding

5 (2.8)

2 (1.1)

1.6

− 1.8 to 5.1

0.46

 Intracranial bleeding

1 (0.6)

1 (0.6)

− 0.01

− 1.6 to 1.5

1.00

 Post-surgical bleeding

5 (2.8)

4 (2.3)

0.52

− 3.2 to 4.3

1.00

 Genitourinary bleeding

5 (2.8)

5 (2.8)

− 0.05

− 3.5 to 3.4

1.00

  1. Primary and secondary outcomes during ICU stay among 357 patients with critical COVID-19 by dose of dexamethasone. Values are expressed as no. (%)
  2. CI confidence interval, GI gastrointestinal
  3. aTwo sample test for equality of proportions; 2-sample test for equality of proportions without continuity correction