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Annals of Intensive Care
Fig. 4 | Annals of Intensive Care

Fig. 4

From: Intravenous vitamin C monotherapy in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis

Fig. 4

Trial sequential analysis for overall mortality. DARIS: diversity-adjusted required information size; RRR: relative risk reduction. The Z curve in blue measures the treatment effect (pooled relative risk). The green parallel lines are the boundaries of conventional naïve alpha of 5%, and the TSA boundaries are in red. A treatment effect outside the TSA boundaries of benefit or harm indicates that there is reliable evidence for a treatment effect, and a treatment effect within the futility zone (the triangle between the green parallel lines) indicates that there is reliable evidence of no treatment effect

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