Relative Risk reduction, % | Control group event rate, % | I2, % | D2, % | RIS | RIS achieved | TSA adjusted RR (95% CI) | Results |
---|---|---|---|---|---|---|---|
Overall analysis (16 studies; n = 2130) | |||||||
 30% | 35% | 42 | 62 | 2110 | - | 0.731 (0.595–0.897) | Sig risk reduction |
 25% | 35% | 42 | 62 | 3090 | - | 0.731 (0.563–0.949) | Sig risk reduction |
 20% | 35% | 42 | 62 | 4902 | 43.5% | 0.731 (0.532–1.003) | Trend to sig reduction |
Subgroup with lower control group mortality (8 studies; n = 1337) | |||||||
 30% | 30% | 18 | 60 | 2489 | 53.7% | 0.889 (0.605–1.307) | Uncertain |
 25% | 30% | 18 | 60 | 3653 | 36.6% | 0.889 (0.560–1.412) | Uncertain |
 20% | 30% | 18 | 60 | 5811 | 23.0% | 0.889 (0.496–1.596) | Uncertain |
Subgroup with higher control group mortality (8 studies; n = 793) | |||||||
 30% | 45% | 0 | 0 | 545 | – | 0.651 (0.530–0.801) | Sig risk reduction |
 25% | 45% | 0 | 0 | 793 | – | 0.651 (0.535–0.793) | Sig risk reduction |
 20% | 45% | 0 | 0 | 1251 | – | 0.651 (0.506–0.839) | Sig risk reduction |