Table 2 Characteristics of ICU stay according to proposed IrAE causality at ICU discharge (n = 110 patients)
From: ICU admission for solid cancer patients treated with immune checkpoint inhibitors
All n = 110 | Unlikely causality n = 66 (60) | Likely causality n = 44 (38) | P-value | |
|---|---|---|---|---|
At ICU admission | ||||
SAPS II | 40 [34–50] Miss. = 10 | 42 [34–49] Miss. = 5 | 39 [34–52] Miss. = 5 | 0.84 |
Reason for ICU admission | 0.09 | |||
Respiratory | 66 (60) | 38 (58) | 28 (64) | |
Colitis | 14 (13) | 8 (12) | 6 (14) | |
Cardiovascular | 13 (12) | 12 (18) | 1 (2) | |
Metabolic | 11 (10) | 5 (8) | 6 (14) | |
Neurologic | 6 (5) | 3 (5) | 3 (7) | |
During ICU stay | ||||
Corticosteroids | 54 (49) | 17 (26) | 37 (84) | < 10–4 |
Vasopressor | 26 (24) | 14 (21) | 12 (27) | 0.46 |
High flow oxygen | 41 (37) | 20 (30) | 21 (48) | 0.06 |
NIV | 22 (24) | 14 (21) | 8 (18) | 0.70 |
IV | 25 (23) | 13 (20) | 12 (27) | 0.35 |
ECMO | 1 (1) | 1 (2) | 0 | … |
Dialysis | 6 (5) | 3 (5) | 3 (7) | … |
Treatment-limitation decisions | 54 (49) | 35 (53) | 19 (43) | 0.31 |