Attributable mortality due to nosocomial sepsis in Brazilian hospitals: a case–control study

Annals of Intensive Care

Table 1 Sepsis definitions used for analysis

	Antibiotic prescribed	Organ failure	Cultures	Other clinically relevant event	Sepsis source information available	Part of alternative definition 1	Part of alternative definition 2
Primary definition
Main sepsis definition	Yes	Yes	Positive or negative	No	Yes	–	–
Alternative definition
Definitive	Yes	Yes	Positive	No	Yes	Yes	Yes
Very probable, either:
(1) or	Yes	Yes	Positive	Yes	Yes	Yes	Yes
(2) or	Yes	Yes	Negative	No	Yes	Yes	Yes
(3)	Yes	Yes	Negative	Yes	Yes	Yes	Yes
Probable	No	Yes	NA^a	No	No	Yes	No
Possible	No	Yes	NA^a	Yes	No	No	No
SOFA increase definition based on Sepsis 3 (post hoc)
SOFA definition (“Sepsis 3”)	Yes	Yes	–		Variable	No	No

NA data not collected
^aData on cultures were only collected for patients that received antibiotics. SOFA definition was performed post hoc. Any patients that had an increase in SOFA score of at least 2 points over baseline (hospital admission) SOFA and that either were started antibiotics or received new antibiotics were considered as septic