Table 2 Admission baseline characteristics
|  | Piperacillin-tazobactam (N = 704) | Meropenem (N = 275) | Admissions where both MEM and TZP were used (N = 97) |
|---|---|---|---|
Demographics | |||
 Age (years) | 62.5 [48.0–72.0] | 65 [51.0–73.0] | 62 [49.0–72.0] |
 Gender (% male) | 63.9 | 67.6 | 67 |
 BMI | 24.97 [22.59–28.4] (699) | 26.12 [23.46–29.41] (273) | 26.21 [23.7–29.04] |
Race | |||
 Caucasian | 96.4% | 96.4% (274) | 97.0% |
 Black | 0.7% | 0.4% (274) | 0.0% |
 Asian | 0.6% | 0.4% (274) | 0.0% |
 Other | 1.3% | 1.4% (274) | 3.0% |
 Not specified | 1.0% | 1.4% (274) | 0.0% |
Comorbidities | |||
 Baseline creatinine (mg/dL) | 0.83 [0.68–1.15] (599) | 0.84 [0.66–1.2] (229) | 0.84 [0.68–1.16] |
 Baseline kidney function | |||
  Unknown | 14.91% | 16.73% | 0% |
  KDIGO G1 | 41.34% | 37.45% | 39.18% |
  KDIGO G2 | 27.30% | 23.64% | 20.62% |
  KDIGO G3a | 9.09% | 7.64% | 8.25% |
  KDIGO G3b | 5.40% | 6.55% | 6.19% |
  KDIGO G4 | 2.56% | 4.36% | 3.09% |
  KDIGO G5 | 1.14% | 1.45% | 2.06% |
  RRT | 2.27% | 2.18% | 1.03% |
  SOFA on admission | 7.0 [4.0–11.0] (697) | 8.0 [4.0–12.0] (270) | 10.0 [5.0–13.0] |
  Apache 4 score on admission | 106 [79.0–134] | 118 [88.0–148.0] | 118 [88.–152.0] |
Reason for ICU admission | |||
 Monitoring or post op management | 36.6% | 28.4% | 22.7% |
 Respiratory failure | 13.9% | 17.5% | 16.5% |
 Septic shock | 12.2% | 18.5% | 17.5% |
 Hypovolemic/hemorrhagic shock | 7.5% | 5.8% | 8.2% |
 Severe sepsis | 6.4% | 10.5% | 9.2% |
 Other | 23.4% | 19.3% | 25.9% |
Surgery as part of reason for admission | |||
 No surgery | 43.8% | 58.5% | 55.7% |
 Planned surgery | 28.6% | 19.6% | 18.6% |
 Emergency surgery | 27.5% | 21.8% | 25.8% |
Disease severity | |||
 SOFA on starting day AB | 8.0 [5.0–11.0] (702) | 8.0 [4.0–12.0] (270) | 10 [6.0–10.0] |
Outcomes | |||
 ICU length of Stay | 7.0 [3.0–17.0] | 13.0 [6.0–25.0] | 23.79 [14.0–33.1] |
 ICU mortality | 15.20% | 20.70% | 20.60% |