Complete case analysis—Model including only Frailty (n = 22,044) | |||
HR1 (95%CI) | P-value | ||
Frailty | vulnerable (CFS 4) | 1.26 (1.11–1.43) | 0.00024 |
frail (CFS 5–8) | 1.59 (1.53–1.66) | < 0.0001 | |
Models including all variables available at baseline | |||
Complete Case Analysis—Model including SOFA as severity index (n = 20,767) | |||
HRa (95%CI) | P-value | ||
Frailty | vulnerable (CFS 4) | 1.07 (1.03–1.1) | 0.00054 |
frail (CFS 5–8) | 1.26 (1.15–1.38) | < 0.0001 | |
Severity | SOFA (one point increase) | 1.17 (1.1–1.23) | < 0.0001 |
Gender | male vs female | 0.97 (0.91–1.04) | 0.3591 |
Age | Age (5 years increase) | 1.11 (1.09–1.13) | < 0.0001 |
Multiple Imputation Analysis—Model including SOFA as severity index | |||
HR1 (95%CI) | P-value | ||
Frailty | vulnerable (CFS 4) | 1.07 (1.03–1.11) | 0.00139 |
frail (CFS 5–8) | 1.28 (1.15–1.41) | < 0.0001 | |
Severity | SOFA (one point increase) | 1.17 (1.11–1.23) | < 0.0001 |
Gender | male vs female | 0.96 (0.9–1.02) | 0.15900 |
Age | Age (5 years increase) | 1.11 (1.09–1.13) | < 0.0001 |