Table 1 Demographic and clinical characteristics of phenotypes
Variable | Phenotype | p-value | ||||||
|---|---|---|---|---|---|---|---|---|
A-very low SOFA | B-respirat. failure | C-oldest old | D-moderate SOFA | E-renal failure | F-geriatric, low SOFA | G-geriatric, high SOFA | ||
Number of patients | 244 | 247 | 134 | 252 | 143 | 106 | 142 | |
Age-median (IQR) | 83 (81–85) | 83 (81–85) | 92 (90–94) | 83 (81–85) | 83 (81–85) | 84 (82–86) | 85 (83–89) | < 0.001 |
Gender-number (% female) | 123 (50%) | 116 (47%) | 83 (61%) | 91 (36%) | 45 (31%) | 68 (64%) | 74 (52%) | < 0.001 |
Admission reason-number (%) | ||||||||
Respiratory/cardiovascular | 58 (23%) | 187 (75%) | 80 (59%) | 119 (47%) | 61 (42%) | 63 (59%) | 73 (51%) | < 0.001 |
Sepsis | 8 (3%) | 16 (6%) | 5 (3%) | 39 (15%) | 26 (18%) | 9 (8%) | 42 (29%) | < 0.001 |
Emergency surgery | 51 (20%) | 20 (8%) | 21 (15%) | 56 (22%) | 11 (7%) | 11 (10%) | 14 (9%) | < 0.001 |
SOFA score-median (IQR) | 1 (0–2) | 4 (3–4) | 4 (2–5) | 7 (7–9) | 6 (5–8) | 3 (2–4) | 11 (10–12) | < 0.001 |
Geriatric featuresa median (IQR) | ||||||||
CFS | 3 (2–3) | 4 (3–4) | 4 (3–5) | 3 (2–4) | 4 (3–4) | 6 (6–7) | 7 (6–7) | < 0.001 |
Katz score | 6 (6–6) | 6 (6–6) | 5 (4–6) | 6 (6–6) | 6 (5–6) | 3 (2–4) | 1 (0–2) | < 0.001 |
IQCODE | 3.1 (3–3.2) | 3.1 (3–3.3) | 3.4 (3.1–3.9) | 3.1 (3–3.3) | 3.2 (3–3.4) | 3.7 (3.2–4) | 4.7 (4.1–5) | < 0.001 |
CPS | 7 (5–10) | 12 (9–14) | 9 (6–12) | 9 (6–12) | 12 (9–16) | 16 (14–20) | 11 (8–14) | < 0.001 |
Interventions-number (%) | ||||||||
Invasive ventilation | 38 (15%) | 88 (35%) | 32 (23%) | 191 (75%) | 33 (23%) | 24 (22%) | 121 (85%) | < 0.001 |
Vasopressors | 50 (20%) | 66 (26%) | 54 (40%) | 249 (98%) | 74 (51%) | 39 (36%) | 136 (95%) | < 0.001 |
Renal replacement therapy | 4 (1%) | 4 (1%) | 0 | 27 (10%) | 62 (43%) | 5 (4%) | 26 (18%) | < 0.001 |
Limitations of LST-number (%) | ||||||||
LST withheld | 26 (10%) | 59 (23%) | 53 (39%) | 68 (27%) | 32 (22%) | 40 (37%) | 58 (40%) | < 0.001 |
LST withdrawn | 5 (2%) | 25 (10%) | 7 (5%) | 31 (12%) | 10 (7%) | 9 (8%) | 16 (11%) | < 0.001 |
LST withheld and withdrawn | 3 (1%) | 15 (6%) | 5 (3%) | 22 (8%) | 9 (6%) | 6 (5%) | 12 (8%) | 0.003 |
Length of stay in ICU (days)-median (IQR) | 2.4 (1.1–4) | 5 (2.2–8.5) | 3 (1.1–5) | 6 (3–12) | 5 (2.7–7.9) | 3 (1.9–6) | 6 (2.5–13) | < 0.001 |
Died in ICU-number (%) | ||||||||
All | 12 (5%) | 30 (12%) | 18 (13%) | 51 (20%) | 22 (15%) | 10 (9%) | 81 (57%) | < 0.001 |
After LST withheld | 6 (23%) | 17 (29%) | 13 (25%) | 27 (40%) | 13 (41%) | 5 (13%) | 35 (60%) | < 0.001 |
(p valueb) | (0.004) | (0.017) | (0.031) | (0.29) | (0.067) | (1.0) | (0.58) | |
Died within 30 days-number (%) | ||||||||
All | 21 (9%) | 52 (21%) | 42 (31%) | 74 (29%) | 33 (23%) | 25 (24%) | 96 (68%) | < 0.001 |
After LST withheld | 11 (42%) | 25 (42%) | 27 (51%) | 39 (57%) | 19 (59%) | 13 (32%) | 44 (76%) | < 0.001 |
(p valueb) | (< 0.001) | (0.004) | (< 0.001) | (0.003) | (< 0.001) | (0.13) | (0.13) | |